10 documents found, page 1 of 1
ABO-incompatible living donor kidney transplantation in Portugal
Ribeiro,Catarina Isabel; Silva,Natália; Malheiro,Jorge; Almeida,Manuela; Pedroso,Sofia; La Salete Martins,Maria; Dias,Leonídio; Henriques,António CastroIntroduction: ABO incompatibility was considered a barrier to kidney transplant. However, the shortage of available organs for transplantation and the excellent long-term results further establish ABO-incompatible (ABOi) as a safe and effective therapeutic strategy. The aim of the present study was to evaluate the outcomes of ABOi transplantation in terms of graft survival and function, rejection episodes and i...
Rituximab-induced hypersensitivity pneumonitis in a kidney transplant patient
Silva,Natália; Ribeiro,Catarina Isabel; Almeida,Manuela; Malheiro,Jorge; Pedroso,Sofia; Martins,Maria La Salete; Dias,Leonídio; Henriques,António CastroRituximab (RTX) is a chimeric anti-CD20 monoclonal antibody that has been associated with delayed pulmonary toxicity. In patients receiving RTX, hypersensitivity pneumonitis, although rare, should be considered in the appropriate clinical and radiographic setting. The authors present a case of hypersensitivity pneumonitis associated with a single dose of RTX treatment in a kidney transplanted patient with acute...
Kidney transplantation in patients with preformed and exclusively anti-HLA-Cw d...
Santos,Sofia; Castro,Ana; Campos,Andreia; Pedroso,Sofia; Dias,Leonídio; Henriques,CastroWe report a patient who had received a first kidney transplant and had preformed DSA anti-HLA-Cw, developing AMR C4d+ soon after transplant. Classically anti-HLA-Cw are considered less immunogenic and are not considered in many organ allocation systems or immunologic risk stratification algorithms, including in Portugal. However, data from literature confirms that their presence is as deleterious as DSA anti-HL...
Implications for patients waiting for a kidney transplant of using the calculat...
Magriço,Rita; Malheiro,Jorge; Tafulo,Sandra; Pedroso,Sofia; Almeida,Manuela; ,La Salete; Dias,Leonídio; Castro-Henriques,António; Cabrita,AntónioIntroduction: Kidney transplant improves survival even in highly-sensitized(HS) patients. To overcome their disadvantage in accessing transplantation, those with high Complement Dependent Cytotoxic PRA (CDC-PRA) receive additional points during allocation. Whether this strategy reaches all HS patients and how long they wait for a transplant is largely undetermined. Methods: Patients on our units active wait-li...
Malignancy after renal transplantation: a single-centre experience
Vieira,Pedro; Barreto,Patrícia; Pedroso,Sofia; Almeida,Manuela; Martins,La Salete; Dias,Leonídio; Henriques,António Castro; Cabrita,AntónioIntroduction: Malignancy management in renal transplant recipients is becoming a major factor affecting long-term patient survival. Thus, we intended to evaluate both incidence and prognosis of malignant diseases following renal transplantation at a single centre in Portugal. Methods: We studied retrospectively the 2,358 patients who underwent kidney transplantation (KT) between 1983 and 2014. Apart from descri...
BK virus nephropathy in kidney transplantation: A literature review following a...
Barreto,Patrícia; Almeida,Manuela; Dias,Leonídio; Vieira,Pedro; Pedroso,Sofia; Martins,La Salete; Henriques,António Castro; Cabrita,AntónioOver the last 15 years, better immunosuppressive drugs have decreased acute rejection rates in kidney transplantation but have also led to an increase in the incidence and impact of BK virus nephropathy. The authors report the case of a 62--year-old man submitted to a renal transplant of a deceased donor with an immunosuppression regimen free of rabbit anti -thymocyte globulin and tacrolimus, in whom BK nephrop...
Impact of pre-transplant anti-MICA sensitization in graft rejection and survival
Costa,Rui; Malheiro,Jorge; Tafulo,Sandra; Santos,Clara; Almeida,Manuela; Pedroso,Sofia; Martins,La Salete; Dias,Leonídio; Castro-Henriques,AntónioBackground: Evidence supporting deleterious effect of preformed major histocompatibility class I chain-related A (MICA) antibodies in rejection incidence and graft survival is still unclear. Methods: Retrospective analysis of 554 kidney transplanted patients. Comparison between positive or negative for MICA antibodies patients was performed to characterize sensitizing triggers. Further classification according ...
Transplantação renal pediátrica: experiência de um centro
Nascimento,João; Rocha,Liliana; Faria,Maria Sameiro; Matos,Paula; Costa,Teresa; Martins,Maria Lassalete; Almeida,Manuela; Dias,Leonídio; Mota,ConceiçãoIntrodução: A insuficiência renal crónica terminal está associada a numerosas comorbilidades e a um aumento do risco de mortalidade cerca de 30 vezes superior à população pediátrica geral. O primeiro transplante renal bem sucedido em crianças foi realizado em 1954. Os progressos cirúrgicos e as novas terapêuticas imunossupressoras aumentaram a sobrevida dos doentes e do enxerto renal nos últimos anos. Objectivo...
Tacrolimus: a forgotten agent in kidney transplant leukopenia
Azevedo,Pedro; Freitas,Cristina; Silva,Hugo; Aguiar,Pedro; Santos,Teresa; Cabral,João; Rocha,Guilherme; Almeida,Manuela; Pedroso,SofiaLeukopenia in kidney transplant patients is frequent, it causes potentially life-threatening complications, but it is often poorly characterized. Opportunistic infections, immunologic disturbances and drug-related toxicity are principal causes of single or multilineage cytopenias. Tacrolimus-induced leukopenia is a less recognized but frequent complication. We describe one patient with leukopenia developing wit...
Pericardial and pleural effusions associated with sirolimus and discussion of p...
Rocha,Sofia; Pedroso,Sofia; Almeida,Manuela; Dias,Leonídio; Martins,La Salete; Henriques,António C.; Cabrita,AntónioSirolimus, a mammalian target of rapamycin inhibitor, is an increasingly used immunosuppressant in solid-organ transplantation. There are an increasing number of reports of unusual oedematous adverse effects associated with this drug, including lymphoedema, ascites and pleural effusions, and a few reports of pericardial effusions. No pathophysiological explanation for these phenomena has been disclosed. We repo...