5 documents found, page 1 of 1
Exploring quercetin's potential to counteract intestinal pro-inflammatory effec...
Sousa, Adelaide; Azevedo, Rui; Costa, Vera M.; Oliveira, Sara; Viana, Sofia; Reis, Flávio; Almeida, Agostinho; Matafome, Paulo; Dias-Pereira, PatríciaBackground: Silver nanoparticles (AgNP) elicit an intestinal response characterized by vascular and cellular changes, alongside the release of cytokines linked to the activation of the nuclear factor-кB (NF-кB) pathway. Consequently, a search was conducted for a compound capable of counteracting the primary pro-inflammatory effects induced by these nanoparticles [1]. Given the reported anti-inflammatory propert...
Biodistribution and intestinal inflammatory response following voluntary oral i...
Sousa, Adelaide; Azevedo, Rui; Costa, Vera Marisa; Oliveira, Sara; Preguiça, Inês; Viana, Sofia; Reis, Flávio; Almeida, Agostinho; Matafome, Paulo N.Silver nanoparticles (AgNP) are among the most widely commercialized nanomaterials globally, with applications in medicine and the food industry. Consequently, the increased use of AgNP in the food industry has led to an unavoidable rise in human exposure to these nanoparticles. Their widespread use raises concerns about potential hazards to human health, specifically their intestinal pro-inflammatory effects....
Pd2Spermine Complex Shows Cancer Selectivity and Efficacy to Inhibit Growth of ...
Vojtek, Martin; Gonçalves-Monteiro, Salomé; Šeminská, Patrícia; Valová, Katarína; Bellón, Loreto; Dias-Pereira, Patrícia; Marques, FranklimPd2Spm is a dinuclear palladium(II)-spermine chelate with promising anticancer properties against triple-negative breast cancer (TNBC), a breast carcinoma subset with poor prognosis and limited treatment options. The present study evaluated the in vitro and in vivo anticancer effects of Pd2Spm compared to the reference metal-based drug cisplatin. Triple-negative breast cancer MDA-MB-231 cells, non-cancerous MCF...
Cross Species Analysis and Comparison of Tumors in Dogs and Cats, by Age, Sex, ...
Pinello, Katia; Pires, Isabel; Castro, Ana Filipa; Carvalho, Paulo Tiago; Santos, Andreia; Matos, Augusto; Queiroga, Felisbina; Canadas-Sousa, AnaThe animal cancer burden is essential for the translational value of companion animals in comparative oncology. The present work aims to describe, analyze, and compare frequencies and associations of tumors in dogs and cats based on the Animal Cancer Registry created by Vet-OncoNet. With 9079 registries, regarding 2019 and 2020, 81% (n = 7355) belonged to dogs. In comparison, cats have a general one-year right ...
Pullulan microneedle patches for the efficient transdermal administration of in...
Fonseca, Daniela F. S.; Costa, Paulo C.; Almeida, Isabel F.; Dias-Pereira, Patrícia; Correia-Sá, Inês; Bastos, Verónica; Oliveira, HelenaThe present study reports the fabrication of dissolvable microneedle (MN) patches using pullulan (PL), a water-soluble polysaccharide with excellent film-forming ability, for the transdermal administration of insulin, envisioning the non-invasive treatment of diabetes. PL MNs patches were successfully prepared by micromoulding and revealed good thermal stability (Tdmax = 294 °C) and mechanical properties (>0.15...