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Predictive factors of long-term visual outcomes after primary Descemet’s membra...

Moura-Coelho, Nuno; Papa-Vettorazzi, Renato; Dias-Santos, Arnaldo; Cunha, João Paulo; Dutra-Medeiros, Marco; Manero, Felicidad; Güell, José Luis

Purpose: To determine predictive factors of higher levels of best-corrected visual acuity (BCVA) in the long-term after primary Descemet's membrane endothelial keratoplasty (DMEK). Methods: Retrospective, single-surgeon case series of 129 successful primary DMEK eyes without graft failure and with a minimum postoperative follow-up of 12 months. A mixed effect model for repeated measurements (MMRM) analysis was ...


Acute Syphilitic Posterior Placoid Chorioretinitis

Maleita, Diogo; Dias-Santos, Arnaldo; Anjos, Rita


Outcomes of cystoid macular edema following Descemet’s membrane endothelial ker...

Moura-Coelho, Nuno; Papa-Vettorazzi, Renato; Santiesteban-García, Imalvet; Dias-Santos, Arnaldo; Manero, Felicidad; Cunha, João Paulo; Güell, José

The aim of this study was to analyze the outcomes of eyes with visually significant cystoid macular œdema (vs-CMO) after Descemet membrane endothelial keratoplasty (DMEK) in a referral center for keratoplasty in Spain. We conducted a retrospective, single-surgeon case series of eyes that developed post-DMEK vs-CMO performed between January 2011 and December 2020. Data collected included: indication for DMEK; bi...


Descemet’s membrane endothelial keratoplasty for corneal endothelial failure se...

Moura-Coelho, Nuno; Cunha, João Paulo; Dias-Santos, Arnaldo; Dutra-Medeiros, Marco; Papa-Vettorazzi, Renato; Manero, Felicidad; Güell, José

Purpose: To analyze the outcomes of Descemet's membrane endothelial keratoplasty (DMEK) for corneal endothelial failure secondary to phakic intraocular lens implantation (PIOL) at a reference center for corneal transplantation in Spain. Design: Retrospective, single-surgeon case series. Methods: Single-center analysis of patients who underwent DMEK for PIOL-related corneal decompensation between July 2011 and J...


Neurodegeneration in systemic lupus erythematosus: layer by layer retinal study...

Dias-Santos, Arnaldo; Tavares Ferreira, Joana; Pinheiro, Sofia; Cunha, João Paulo; Alves, Marta; Papoila, Ana L.; Moraes-Fontes, Maria Francisca

Systemic lupus erythematosus (SLE) is a chronic, autoimmune and multisystemic disease. Recent studies with functional and structural magnetic resonance imaging and cognitive tests report an unexpectedly high frequency of central nervous system involvement, even in patients with asymptomatic SLE. The purpose of this study was to identify early signs of retinal neurodegeneration by comparing the thickness of the ...


Choroidal thickness changes in systemic lupus erythematosus patients

Dias-Santos, Arnaldo; Tavares Ferreira, Joana; Pinheiro, Sofia; Cunha, João Paulo; Alves, Marta; Papoila, Ana Luísa; Moraes-Fontes, Maria Francisca

Purpose: To compare choroidal thickness (CT) between patients with systemic lupus erythematosus (SLE) without ophthalmologic manifestations and a control group. To study the effects in CT of disease duration, activity index, medication and systemic comorbidities. Methods: Cross-sectional study where spectral-domain optical coherence tomography with enhanced depth imaging was used to measure CT in 13 locations, ...


Expression of Focal Adhesion Kinase in Retinoblastoma

Dias-Santos, Arnaldo; Bravo-Filho, Vasco; Faingold, Dana; Odashiro, Alexandre; Odashiro, Padrícia; Jagan, Lisa; Ballazsi, Matthew; Burnier Jr, Miguel

Introdução: As cinases de adesão focal (CAF) são tirosina-cinases citoplasmáticas, não receto- ras, importantes e no processo oncogénico. O objetivo deste estudo é avaliar o nível de expressão das CAF no retinoblastoma e correlacioná-la com fatores prognósticos histopatológicos. Material e Métodos: a expressão de CAF e da sua forma ativa fosforilada - CAF [pY397] - foi avaliada em vinte espécime...


The impact of multifocal intraocular lens in retinal imaging with optical coher...

Dias-Santos, Arnaldo; Costa, Lívio; Lemos, Vanessa; Anjos, Rita; Vicente, André; Ferreira, Joana; Cunha, João Paulo

Introdução: As lentes intraoculares multifocais (LIOs MF) têm óticas com vários anéis con- cêntricos com diferentes potências dióptricas, permitindo uma boa acuidade visual em várias distâncias focais. No entanto, tal design associa-se a algumas limitações óticas. O objetivo deste estudo é avaliar o impacto das LIOs MF na precisão e qualidade das imagens de tomografia de coerência ótica (OCT)....


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