5 documents found, page 1 of 1
Synthesis approaches to (−)-cytoxazone, a novel cytokine modulator, and related...
Diaz, Marisa A. N.; Miranda, Izabel L.; Lopes, Ítala K. B.; Diaz, Gaspar(−)-Cytoxazone, originally isolated from cultures of a Streptomyces species has an oxazolidin-2-one 4,5-disubstituted ring. It is known that this natural product presents a cytokine modulator effect through the signaling pathway of Th2 cells (type 2 cytokines), which are involved in the process of growth and differentiation of cells. From this, the interest in the development of research aimed at the total synt...
Antibiotic activity of plectranthus ornatus codd., a traditional medicinal plant
Nascimento, Fernanda R.; Albuquerque, Kamylla R.S.; Oliveira, Marcos R.; Pizziolo, Virginia R.; Brasileiro, Beatriz G.; Diaz, Gaspar; Diaz, Marisa A.N.The dichloromethane extract of Plectranthus ornatus Codd., a tradicional medicinal plant, showed antibiotic activity with minimum inhibitory concentration (MIC) values of 0.4 mg.mL-1 and 100 percent of biofilm inhibition against Staphylococcus aureus strains isolated from animals with mastitis infections. Based on these antibacterial activities, in addition to ethnopharmacological reports from healing men and f...
Easy access to evans’ oxazolidinones. Stereoselective synthesis and antibacteri...
Diaz, Gaspar; Freitas, Michelle A. A. de; Ricci-Silva, Maria E.; Diaz, Marisa A. N.An interesting new approach was developed for the synthesis of Evans’ chiral auxiliaries with excellent yields. In turn, another new stereoselective and efficient strategy has also allowed for the preparation of a 2-oxazolidinone derivative in 34% overall yield from the Morita-Baylis-Hillman adduct. The antibacterial activity of this oxazolidinone was tested against Staphylococcus aureus strains isolated from a...
Chemical constituents and an alternative medicinal veterinary herbal soap made ...
Andrade, Flávia Inoue; Purgato, Gislaine Aparecida; Maia, Thalita de Faria; Siqueira, Raoni Pais; Lima, Sâmia; Diaz, Gaspar; Diaz, Marisa Alves NogueiraUpon undergoing biomonitoring, the most active dichloromethane extract retrieved from Senna macranthera roots led to the isolation of three main compounds: emodine, physione, and chrysophanol. In this sequence, these compounds revealed a potential antibacterial activity against Staphylococcus aureus strains isolated from animals with mastitis infections with minimum inhibitory concentration (MIC) values of 20, ...
Synthesis approaches to ( − )-cytoxazone, a novel cytokine modulator, and relat...
Miranda, Izabel L.; Lopes, Itala K. B.; Diaz, Marisa A. N.; Diaz, Gaspar(−)-Cytoxazone, originally isolated from cultures of a Streptomyces species has an oxazolidin-2-one 4,5-disubstituted ring. It is known that this natural product presents a cytokine modulator effect through the signaling pathway of Th2 cells (type 2 cytokines), which are involved in the process of growth and differentiation of cells. From this, the interest in the development of research aimed at the total synt...