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Obstructive Sleep Apnea as an Aging Trigger: from Mechanisms to Biomarkers
Gaspar, Laetitia da SilvaTese de Doutoramento em Biologia Experimental e Biomedicina apresentada ao Instituto de Investigação Interdisciplinar; A Síndrome da Apneia Obstrutiva do Sono (SAOS) é uma das perturbações mais comuns no mundo, com um impacto muito significativo na saúde, economia e sociedade. Contudo, existem ainda várias dificuldades no seu diagnóstico e tratamento. E, não tratada, a SAOS tem sido associada ao desenvolvimento...
Trehalose alleviates the phenotype of Machado-Joseph disease mouse models
Santana, Magda M.; Paixão, Susana; Cunha-Santos, Janete; Silva, Teresa Pereira; Trevino-Garcia, Allyson; Gaspar, Laetitia da Silva; Nóbrega, ClévioBackground: Machado–Joseph disease (MJD), also known as spinocerebellar ataxia type 3, is the most common of the dominantly inherited ataxias worldwide and is characterized by mutant ataxin-3 aggregation and neuronal degeneration. There is no treatment available to block or delay disease progression. In this work we investigated whether trehalose, a natural occurring disaccharide widely used in food and cosmeti...
Simple and Fast SEC-Based Protocol to Isolate Human Plasma-Derived Extracellula...
Gaspar, Laetitia da Silva; Santana, Magda M.; Henriques, Carina; Pinto, Maria M.; Ribeiro-Rodrigues, Teresa M.; Girão, Henrique; Nobre, Rui JorgeExtracellular vesicles (EVs) are membranous structures that protect RNAs from damage when circulating in complex biological fluids, such as plasma. RNAs are extremely specific to health and disease, being powerful tools for diagnosis, treatment response monitoring, and development of new therapeutic strategies for several diseases. In this context, EVs are potential sources of disease biomarkers and promising d...
Clock genes profile as disease biomarkers
Gaspar, Laetitia da SilvaDissertação de Mestrado em Biologia Celular e Molecular, apresentada ao Departamento de Ciências da Vida da Faculdade de Ciências e Tecnologia da Universidade de Coimbra.; Circadian rhythms, defined by a set of biological clocks, are crucial to virtually all biological processes. A central clock is located in the hypothalamus and synchronises peripheral clocks, located in all cells. Disruptions in this complex ...