12 documents found, page 1 of 2
Early alveolar macrophage response and IL-1R-dependent T cell priming determine...
Lovey, Arianne; Verma, Sheetal; Kaipilyawar, Vaishnavi; Ribeiro-Rodrigues, Rodrigo; Husain, Seema; Palaci, Moises; Dietze, Reynaldo; Ma, ShuyiFunding Information: The work was funded by the National Institute of Allergy and Infectious Diseases, National Institutes of Health grants U19AI111276 and U01AI065663 to R.R.R., R.D., J.J.E. and P.S., and NIAID training grant T32AI125185 to A.L. The study sponsors were not involved in the study design, in the collection, analysis, and interpretation of data; in the writing of the manuscript; or in the decision...
Increase of cd4+cd25highfoxp3+ cells impairs in vitro human microbicidal activi...
Stringari, Lorenzzo Lyrio; Covre, Luciana Polaco; da Silva, Flávia Dias Coelho; de Oliveira, Vivian Leite; Campana, Maria Carolina; Hadad, David Jamil50204076]. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Publisher Copyright: © 2021 Stringari et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credit...
Covert cases of severe acute respiratory syndrome Coronavirus 2
Stringari, Lorenzzo Lyrio; de Souza, Michel Norbim; de Medeiros Junior, Nésio Fernandes; Goulart, Jaqueline Pegoretti; Giuberti, CamilaBACKGROUND: The impact of SARS-CoV-2 in regions endemic for both Dengue and Chikungunya is still not fully understood. Considering that symptoms/clinical features displayed during Dengue, Chikungunya and SARS-CoV-2 acute infections are similar, undiagnosed cases of SARS-CoV-2 in co-endemic areas may be more prevalent than expected. This study was conducted to assess the prevalence of covert cases of SARS-CoV-2 ...
Mycobacterium tuberculosis progresses through two phases of latent infection in...
Colangeli, Roberto; Gupta, Aditi; Vinhas, Solange Alves; Chippada Venkata, Uma Deepthi; Kim, Soyeon; Grady, Courtney; Jones-López, Edward C.Little is known about the physiology of latent Mycobacterium tuberculosis infection. We studied the mutational rates of 24 index tuberculosis (TB) cases and their latently infected household contacts who developed active TB up to 5.25 years later, as an indication of bacterial physiological state and possible generation times during latent TB infection in humans. Here we report that the rate of new mutations in...
Efficient transplacental IgG transfer in women infected with Zika virus during ...
Singh, Tulika; Lopez, Cesar A.; Giuberti, Camila; Dennis, Maria L.; Itell, Hannah L.; Heimsath, Holly J.; Webster, Helen S.; Roark, Hunter K.Zika virus (ZIKV) is a newly-identified infectious cause of congenital disease. Transplacental transfer of maternal IgG to the fetus plays an important role in preventing many neonatal infections. However, antibody transfer may also have negative consequences, such as mediating enhancement of flavivirus infections in early life, or trafficking of virus immune complexes to the fetal compartment. ZIKV infection p...
Host determinants of infectiousness in smear-positive patients with pulmonary t...
Acuña-Villaorduña, Carlos; Ayakaka, Irene; Schmidt-Castellani, Luiz Guilherme; Mumbowa, Francis; Marques-Rodrigues, Patricia; Gaeddert, MaryBackground Epidemiologic data suggests that only a minority of tuberculosis (TB) patients are infectious. Cough aerosol sampling is a novel quantitative method to measure TB infectiousness. Methods We analyzed data from three studies conducted in Uganda and Brazil over a 13-year period. We included sputum acid fast bacilli (AFB) and culture positive pulmonary TB patients and used a cough aerosol sampling system...
Transmission phenotype of mycobacterium tuberculosis strains is mechanistically...
Verma, Sheetal; Bhatt, Kamlesh; Lovey, Arianne; Ribeiro-Rodrigues, Rodrigo; Durbin, Joan; Jones-López, Edward C.; Palaci, Moises; Vinhas, Solange A.In a study of household contacts (HHC), households were categorized into High (HT) and Low (LT) transmission groups based on the proportion of HHC with a positive tuberculin skin test. The Mycobacterium tuberculosis (Mtb) strains from HT and LT index cases of the households were designated Mtb-HT and Mtb-LT, respectively. We found that C3HeB/FeJ mice infected with Mtb-LT strains exhibited significantly higher b...
Circulating senescent T cells are linked to systemic inflammation and lesion si...
Covre, Luciana P.; Martins, Régia F.; Devine, Oliver P.; Chambers, Emma S.; Vukmanovic-Stejic, Milica; Silva, Juliana A.; Dietze, ReynaldoLeishmania (Viannia) braziliensis induces American tegumentary leishmaniasis that ranges in severity from the milder form, cutaneous (CL) to severe disseminated cutaneous leishmaniasis. Patients with CL develop a cell-mediated Th1 immune response accompanied by production of inflammatory cytokines, which contribute to parasite control and pathogenesis of disease. Here, we describe the accumulation of circulatin...
Cough-Aerosol cultures of Mycobacterium tuberculosis in the prediction of outco...
Acuña-Villaorduña, Carlos; Schmidt-Castellani, Luiz Guilherme; Marques-Rodrigues, Patricia; White, Laura F.; Hadad, David Jamil; Gaeddert, MaryBackground Mycobacterium tuberculosis cultures of cough-generated aerosols from patients with pulmonary tuberculosis (TB) are a quantitative method to measure infectiousness and to predict secondary outcomes in exposed contacts. However, their reproducibility has not been established. Objective To evaluate the predictive value of colony-forming units (CFU) of M.Tuberculosis in cough aerosols on secondary infect...
A Leishmania infantum genetic marker associated with miltefosine treatment fail...
Carnielli, Juliana B.T.; Crouch, Kathryn; Forrester, Sarah; Silva, Vladimir Costa; Carvalho, Sílvio F.G.; Damasceno, Jeziel D.; Brown, ElaineBackground: Miltefosine has been used successfully to treat visceral leishmaniasis (VL) in India, but it was unsuccessful for VL in a clinical trial in Brazil. Methods: To identify molecular markers that predict VL treatment failure whole genome sequencing of 26 L. infantum isolates, from cured and relapsed patients allowed a GWAS analysis of SNPs, gene and chromosome copy number variations. Findings: A strong ...