6 documents found, page 1 of 1
Cumulative Effect of Cardiovascular Risk Factors on Regulation of AMPK/SIRT1-PG...
Pereira, AS; Gouveia, Alexandra; Tomada, N; Rodrigues, AR; D NevesCardiovascular disease risk factors (CVDRF), especially diabetes mellitus (DM), disrupt oxidative stress response. This condition underlies endothelial dysfunction, early manifested in men as erectile dysfunction. The current study is aimed at elucidating the impact of CVDRF in the oxidation responsive AMPK/SIRT1-PGC-1 alpha-SIRT3 pathway and related miRNAs in the human corpus cavernosum. Human penile tissue fr...
Cumulative Effect of Cardiovascular Risk Factors on Regulation of AMPK/SIRT1-PG...
Pereira, AS; Gouveia, AM; Tomada, N; Rodrigues, AR; Neves, DCardiovascular disease risk factors (CVDRF), especially diabetes mellitus (DM), disrupt oxidative stress response. This condition underlies endothelial dysfunction, early manifested in men as erectile dysfunction. The current study is aimed at elucidating the impact of CVDRF in the oxidation responsive AMPK/SIRT1-PGC-1-SIRT3 pathway and related miRNAs in the human corpus cavernosum. Human penile tissue fragment...
The influence of metabolic profile of obese men on the severity of erectile dys...
Moura, A; Tomada, I; Tomada, NObjective: To determine the prevalence of erectile dysfunction (ED) in metabolically healthy obese (MHO) individuals, and to compare ED severity and hypogonadism prevalence in MHO, metabolically unhealthy obese (MUO) and metabolically healthy non-obese individuals.Material and methods: ED patients (n=460) were evaluated by standardized protocol, that included clinical evaluation, abridged 5-item version of the ...
Endothelial function in patients with metabolic syndrome and erectile dysfuncti...
Tomada, N; Tomada, I; Botelho, F; Pacheco-Figueiredo, L; Lopes, T; Negrão, R; Pestana, M; Cruz, FErectile dysfunction (ED) is a highly prevalent disease whose aetiology is mostly vasculogenic. It is nowadays considered a marker of future cardiovascular events reflecting the underlying endothelial dysfunction, the common link with the metabolic syndrome (MetS). The recent association between MetS, endothelial dysfunction and peripheral artery disease, but not with coronary artery disease (CAD), suggests tha...
Metabolic syndrome and erectile dysfunction: Assessing the clinical and hemodyn...
Pacheco-Figueiredo, L; Neves, E; Coutinho, P; Botelho, F; Tomada, I; Tomada, NObjetivos Calcular a prevalência de fatores de risco cardiovascular, incluindo a síndrome metabólica (SM), numa série de doentes portugueses com disfunção erétil (DE) e quantificar o impacto individual e agregado dos mesmos, nos parâmetros hemodinâmicos e no grau de severidade reportada. Material e métodos Estudo de uma série de 408 doentes com DE seguidos em consulta de Urologia, no período 2008-2010. A SM foi...
Real-Time PCR Study of Ang1, Ang2, Tie-2, VEGF, and KDR Expression in Human Ere...
Figueiredo, A; Cordeiro, AL; Tomada, N; Tomada, I; Rodrigues, A; Gouveia, Alexandra; Neves, DIntroduction. Aging is a recognized risk factor for erectile dysfunction (ED), contributing independently to vascular damage of penile tissue. Vascular maintenance depends on angiogenic balance in tissues. Vascular endothelial growth factor (VEGF) is a modulator of endothelial cells functions, after engagement to specific receptor kinase domain region (KDR). Other factors, such as angiopoietins, cross talk wit...