13 documents found, page 1 of 2
The Anti-Neuroinflammatory Role of Anthocyanins and Their Metabolites for the P...
Henriques, Joana F.; Serra, Diana; Dinis, Teresa C. P.; Almeida, Leonor M.Anthocyanins are naturally occurring polyphenols commonly found in fruits and vegetables. Numerous studies have described that anthocyanin-rich foods may play a crucial role in the prevention and treatment of different pathological conditions, which have encouraged their consumption around the world. Anthocyanins exhibit a significant neuroprotective role, mainly due to their well-recognized antioxidant and ant...
An Anthocyanin-Rich Extract Obtained from Portuguese Blueberries Maintains Its ...
Serra, Diana; Henriques, Joana F.; Serra, Teresa; Silva, Andreia Bento; Bronze, Maria Rosário; Dinis, Teresa C. P.; Almeida, Leonor M.Dietary polyphenols are multi-target compounds that have been considered promising candidates in strategies for the mitigation of neurological diseases, acting particularly through reduction of microglia-driven neuroinflammation. In this study, an anthocyanin-rich extract obtained from Portuguese blueberries was subjected to a simulated gastrointestinal digestion; after chemical characterisation, the potential ...
Highlights in BACE1 Inhibitors for Alzheimer's Disease Treatment
Coimbra, Judite R. M.; Marques, Daniela F. F.; Baptista, Salete J.; Pereira, Cláudia Fragão; Moreira, Paula I.; Dinis, Teresa C. P.; Santos, Armanda E.Alzheimer's disease (AD) is a severe neurodegenerative disorder and the most common type of dementia in the elderly. The clinical symptoms of AD include a progressive loss of memory and impairment of cognitive functions interfering with daily life activities. The main neuropathological features consist in extracellular amyloid-β (Aβ) plaque deposition and intracellular Neurofibrillary tangles (NFTs) of hyperpho...
Novel PARP-1 Inhibitor Scaffolds Disclosed by a Dynamic Structure-Based Pharmac...
Baptista, Salete J.; Silva, Maria M. C.; Moroni, Elisabetta; Meli, Massimiliano; Colombo, Giorgio; Dinis, Teresa C. P.; Salvador, Jorge A. R.PARP-1 inhibition has been studied over the last decades for the treatment of various diseases. Despite the fact that several molecules act as PARP-1 inhibitors, a reduced number of compounds are used in clinical practice. To identify new compounds with a discriminatory PARP-1 inhibitory function, explicit-solvent molecular dynamics simulations using different inhibitors bound to the PARP-1 catalytic domain wer...
Resveratrol modulates cytokine-induced Jak/STAT activation more efficiently tha...
Serra, Diana; Rufino, Ana T.; Mendes, Alexandrina F.; Almeida, Leonor M.; Dinis, Teresa C. P.Background: Many advances have been recently made focused on the valuable help of dietary polyphenols in chronic inflammatory diseases. On the other hand, current treatment options for intestinal bowel disease patients are unsatisfying and, for this reason, it is estimated that many patients use dietary supplements to achieve extra benefits. Aim: The aim of this work was to analyze under a mechanistic perspecti...
Cyanidin-3-glucoside suppresses cytokine-induced inflammatory response in human...
Serra, Diana; Paixão, Joana Isabel Félix; Nunes, Carla; Dinis, Teresa C. P.; Almeida, Leonor M.The potential use of polyphenols in the prevention and treatment of chronic inflammatory diseases has been extensively investigated although the mechanisms involved in cellular signaling need to be further elucidated. Cyanidin-3-glucoside is a typical anthocyanin of many pigmented fruits and vegetables widespread in the human diet. In the present study, the protection afforded by cyanidin-3-glucoside against cy...
Protective role of malvidin-3-glucoside on peroxynitrite-induced damage in endo...
Paixão, Joana Isabel Félix; Dinis, Teresa C. P.; Almeida, LeonorThe health-promoted benefits of anthocyanins, including vascular protective effects and antiatherogenic properties, have now been recognized, but the involved molecular mechanisms have not been well elucidated. Following our previous work on cytoprotective mechanisms of some anthocyanins against apoptosis triggered by peroxynitrite in endothelial cells, here we investigated the protective role of malvidin-3-glu...
Fast Three Dimensional Pharmacophore Virtual Screening of New Potent Non-Steroi...
Neves, Marco A. C.; Dinis, Teresa C. P.; Colombo, Giorgio; Melo, M. Luísa Sá eSuppression of estrogen biosynthesis by aromatase inhibition is an effective approach for the treatment of hormone sensitive breast cancer. Third generation non-steroid aromatase inhibitors have shown important benefits in recent clinical trials with postmenopausal women. In this study we have developed a new ligand-based strategy combining important pharmacophoric and structural features according to the postu...
Resveratrol inhibits the mTOR mitogenic signaling evoked by oxidized LDL in smo...
Brito, Paula M.; Devillard, Raphaël; Nègre-Salvayre, Anne; Almeida, Leonor M.; Dinis, Teresa C. P.; Salvayre, Robert; Augé, Nathaliehttp://www.sciencedirect.com/science/article/B6T12-4V0MTG8-1/2/7b7f3913eea3a6f05047e8c1927696a9
Diphenyl diselenide, a simple glutathione peroxidase mimetic, inhibits human LD...
Bem, Andreza Fabro de; Farina, Marcelo; Portella, Rafael de Lima; Nogueira, Cristina Wayne; Dinis, Teresa C. P.; Laranjinha, João A. N.Oxidative modification of low-density lipoprotein (LDL) represents an important factor in atherogenesis. In the present study, we have investigated the antioxidant capability of diphenyl diselenide (PhSe)2, a simple organoseleno compound, against copper (Cu2+) and peroxyl radical-induced human LDL oxidation in vitro. In initial studies using human serum, (PhSe)2 caused a dose-dependent inhibition of Cu2+-induce...