7 documents found, page 1 of 1
II TOXRUN International Congress 2023 | No Boundaries for Toxicology: One Healt...
Dinis-Oliveira, R. J.Welcome to the II TOXRUN INTERNATIONAL CONGRESS, 2023 entitled “No Boundaries For Toxicology: One Health, One Society, One Planet. We intend that this event constitutes a space for approximation between professionals who work in life and health sciences and who see Toxicology as a privileged stage for the understanding that there is only “One Health”, as well as an opportunity for technical-scientific updatin...
Inhibitory activity of psilocybin/psilocin towards the enzymes of the cytochrom...
Brito-da-Costa, A. M.; Silva-Carvalho, M.; Dinis-Oliveira, R. J.; Madureira-Carvalho, Á.; Dias da Silva, D.Background: Psilocybin is a hallucinogen produced by several “magic mushrooms” [1,2]. This prodrug is rapidly metabolized in the organism by alkaline phosphatases and esterases into psilocin, the active drug [1,2]. A scientific gap exists regarding the possible interactions between psilocybin/psilocin and CYP450 enzymes. Since the binding of drugs to CYP450 enzymes can interfere with the metabolism of other sub...
Evaluation of the systemic oxidative stress status upon in vivo exposure to tra...
Cardoso, C.; Dinis-Oliveira, R. J.; Leal, S.; Barbosa, J.; Faria, J.Background: Tramadol and tapentadol are synthetic centrally acting analgesic opioids, used in the treatment of moderate to severe pain [1]. Despite their optimized therapeutic and safety profiles, these compounds are associated with adverse effects, namely CNS and respiratory depression, abuse and dependence [2, 3]. Oxidative stress is one of the main toxicity mechanisms triggered by opioids [1, 4, 5]. Objectiv...
Assessment of the CYP450 inhibitory potential of LSD, 5-MeO-DMT and mescaline: ...
Silva-Carvalho, M.; Brito-da-Costa, A. M.; Dinis-Oliveira, R. J.; Madureira-Carvalho, Á.; Dias da Silva, D.Background: LSD, 5-MeO-DMT and mescaline are classic hallucinogens known for their recreational use, whose consumption increased in the last decades. Despite some available data on the toxicokinetics of these drugs, little is known about their CYP450 metabolism [1,2,3]. Nevertheless, this information is of crucial relevance to predict drug-drug interactions and understand toxicological phenomena, in particular ...
Graphical abstracts in Forensic Sciences – science communication and literacy
Florek, C.; Dinis-Oliveira, R. J.; Soares Carrola, J.Background: Scientific digital communication presents a diversity of add-on summaries to verbal abstracts [1]. Among these native HTML and PDF publications, Graphical Abstracts (GAs) are possibly the oldest [2] and are prevalent in chemistry, medicine, and biology [3]. Even so, some biomedical sub-areas seem to resist to the use of GAs, including the Forensic area. Objective: Review the frequency of GAs in scie...
Shedding light on Portugal’s first major forensic case: elemental analysis of b...
Silva-Bessa, Â.; Azevedo, R.; Almeida, A.; Dinis-Oliveira, R. J.Background: In the late 19th century, Vicente Urbino de Freitas was accused of the death of his nephew, Mário Guilherme Augusto de Sampaio, and his brother-in-law, José António de Sampaio Junior [1-3]. Despite the controversy at the time surrounding the testimonies, autopsy reports and toxicological analyses carried out, Urbino de Freitas was found guilty. After an extensive research and consolidation of all hi...
Nasal colonization by Staphylococcus aureusin Health Sciences students and anal...
Gomes-Sampaio, L. M.; Cláudia-Ferreira, A.; Prata, J. C.; Azevedo, R. M. S.; Pacheco, P.; Campos, Carla; Novais, C.; Peixe, L.; Dinis-Oliveira, R. J.Staphylococcus aureusis the leading bacterial cause of death globally. Nasal carriage of S. aureusincreases the risk of invasive infections, including by methicillin-resistant S. aureus(MRSA) strains, but studies including Portuguese university students (PUS) are scarce. To analyse the prevalence of methicillin-susceptible S. aureus(MSSA) and MRSA among PUS enrolled in different courses/years (1st-4th) at IUCS-...