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GC-MS-Based Study of 14 Cannabinoids Separation in Cannabis sativa L. Extracts ...
Nunes, Bruna A. S.; Capita, Albertina M.; Morais, Ana F.; Dinis-Oliveira, Ricardo J.; Ribeiro, Carlos J. A.; Silva, Eduarda M. P.Background: Cannabinoids from Cannabis sativa L. are increasingly studied due to their potential as medicinal drugs, offering therapeutic benefits such as pain relief and anti-inflammatory effects, while also raising concerns as substances of abuse due to their psychoactive properties [1,2]. Gas chromatography-mass spectrometry (GC-MS) is a powerful tool for identifying and quantifying cannabinoids, offering hi...
L-Threonine Supplementation During Colitis Onset Delays Disease Recovery
Gaifem, Joana; Gonçalves, Luís G.; Dinis-Oliveira, Ricardo J.; Cunha, Cristina; Carvalho, Agostinho; Torrado, EgídioDietary nutrients have emerged as potential therapeutic adjuncts for inflammatory bowel disease (IBD) given their impact on intestinal homeostasis through the modulation of immune response, gut microbiota composition and epithelial barrier stability. Several nutrients have already been associated with a protective phenotype. Yet, there is a lack of knowledge toward the most promising ones as well as the most ad...
Cumulative Mitoxantrone-Induced Haematological and Hepatic Adverse Effects in a...
Rossato, Luciana G.; Costa, Vera M.; Dallegrave, Eliane; Arbo, Marcelo; Dinis-Oliveira, Ricardo J.; Santos-Silva, Alice; Duarte, José A.Mitoxantrone (MTX) is an antineoplastic agent that can induce hepato- and haematotoxicity. This work aimed to investigate the occurrence of cumulative early and late MTX-induced hepatic and haematological disturbances in an vivo model. A control group and two groups treated with three cycles of 2.5 mg/kg MTX at days 0, 10 and 20 were formed. One of the treated groups suffered euthanasia on day 22 (MTX22) to eva...