18 documents found, page 1 of 2
A preliminary assessment of a stool-based microRNA profile for early colorectal...
Santos, Daniela A. R.; Eiras, Mariana; Gonzalez-Santos, Miguel; Santos, Marlene; Pereira, Carina; Santos, Lúcio Lara; Dinis-Ribeiro, Mário; Lima, LuísColorectal cancer screening methods are well established worldwide as a fundamental pilar in CRC management, namely through non-invasive faecal occult blood testing. However, the limited sensitivity of faecal occult blood test for detecting precancerous lesions highlights the need to search for alternative tools, such as microRNAs (miRs). The main aim of this study was to identify stoolbased miR profiles for ea...
The influence of diet and obesity in Lynch syndrome: what do we know so far
Rodrigues, Cláudio; Irving, Susana Couto; Alves, Paula; Dinis-Ribeiro, Mário; Brandão, Catarina; Correia, MartaOf all new cases of colorectal cancer, Lynch syndrome (LS) accounts for approximately 3%. This syndrome is the most common hereditary cancer syndrome and is caused by pathogenic variants in the genes responsible for DNA mismatch repair. Although the relationship between colorectal cancer risk and diet is well established, little is known regarding the influence of diet and nutritional characteristics on LS’s cl...
MicroRNAs Biomarkers for Early Screening of Colorectal Cancer
Santos, Daniela; Gaiteiro, Cristiana; Santos, Marlene; Santos, Lúcio; Dinis-Ribeiro, Mário; Lima, LuísBackground: Colorectal cancer (CRC) is the most incident neoplasia in Portugal [1]. When diagnosed early, the 5-year cancer survival rate increases to 90% [2]. However, the current noninvasive screening method for CRC, Fecal Immunochemical Test (FIT), has low sensitivity and specificity for detecting precancerous lesions [3, 4]. Therefore, it is necessary to develop a new screening method for CRC. MicroRNAs (mi...
MicroRNA biomarkers as promising tools for early colorectal cancer screening—a ...
Santos, Daniela A. R.; Gaiteiro, Cristiana; Santos, Marlene; Santos, Lúcio; Dinis-Ribeiro, Mário; Lima, LuísColorectal cancer (CRC) ranks as the third most prevalent cancer worldwide. Early detection of this neoplasia has proven to improve prognosis, resulting in a 90% increase in survival. However, available CRC screening methods have limitations, requiring the development of new tools. MicroRNA biomarkers have emerged as a powerful screening tool, as they are highly expressed in CRC patients and easily detectable i...
MicroRNAs biomarkers for early screening of colorectal cancer
Santos, Daniela; Gaiteiro, Cristiana; Santos, Marlene; Santos, Lúcio; Dinis-Ribeiro, Mário; Lima, LuísColorectal cancer (CRC) is the most incident neoplasia in Portugal. When diagnosed early, the 5-year cancer survival rate increases to 90% [2]. However, the current noninvasive screening method for CRC, Fecal Immunochemical Test (FIT), has low sensitivity and specificity for detecting precancerous lesions. Therefore, it is necessary to develop a new screening method for CRC. MicroRNAs (miRs) play a role in gene...
Colorectal Screening Program in Northern Portugal: First Findings
Monteiro, Hugo; Tavares, Fernando; Reis, João; Ferreira, Gustavo; Campos, M. José; Costa, Sérgio; Carvalho, Laura; Carvalho, João; Pedroto, IsabelIntroduction: In Portugal, a colorectal cancer screening program based on faecal immunochemical test followed by colonoscopy was shown to be cost-effective for individuals between 50 and 74 years old. We report the first findings of the implementation of a population-based program In Northern Portugal.Material and Methods: In the pilot phase, eligible subjects were allocated either to a direct mailing invitatio...
Correction to the article “Colorectal Screening Program in Northern Portugal: F...
Monteiro, Hugo; Tavares, Fernando; Reis, João; Ferreira, Gustavo; Campos, M. José; Costa, Sérgio; Carvalho, Laura; Carvalho, João; Pedroto, IsabelOn page 168, Table 2, where it reads:On page 168, Table 2, where it reads:Advanced phenotype rate* [n (%)] 35 (49.0) 10 (52.0) 25 (47.0) 0.606Carcinoma** [n (%)] 2 (2.0) 1 (5.0) 1 (2.0)It should read:Advanced phenotype rate [n (%)] 179 (22.0) 57 (30.0) 35 (21.0) 29 (21.0) 24 (14.0) 34 (24.0)Carcinoma [n (%)] 3 (0.4) 2 1On page 168, Table 3, where it reads:ADR (%) 80.0 -Advanced adenoma (%) 44.0 15.9It should re...
Nutritional support of cancer patients without oral feeding: how to select the ...
Nunes, Gonçalo; Fonseca, Jorge; Barata, Ana Teresa; Dinis-Ribeiro, Mário; Pimentel-Nunes, PedroBackground: Digestive tumours are among the leading causes of morbidity and mortality. Many cancer patients cannot maintain oral feeding and develop malnutrition. The authors aim to: review the endoscopic, radiologic and surgical techniques for nutritional support in cancer patients; address the strategies for nutritional intervention according to the selected technique; and establish a decision-making algorith...
Training in endoscopic mucosal resection and endoscopic submucosal dissection: ...
Küttner-Magalhães, Ricardo; Dinis-Ribeiro, Mário; Bruno, Marco J.; Marcos-Pinto, Ricardo; Rolanda, Carla; Koch, Arjun D.Introduction: Endoscopic mucosal resection and endoscopic submucosal dissection are demanding procedures. This study aims to establish face, content and expert validity of the live porcine model in performing endoscopic mucosal resection, endoscopic submucosal dissection, complication management and to assess it as a training tool. Material and methods: Tutors and trainees participating in live porcine model en...
Portuguese Version of the EORTC QLQ-OES18 and QLQ-OG25 for Health-Related Quali...
Relvas-Silva, Miguel; Silva, Rui Almeida; Dinis-Ribeiro, MárioIntroduction: Health-related quality of life assessment is increasingly important as it can help both clinical research and care for patients, particularly among oncological patients. Quality of Life Questionnaire – OES18 (esophageal module) and Quality of Life Questionnaire – OG25 (esophagogastric module) are the European Organization for Research and Treatment of Cancer modules for the evaluation of quality o...