7 documents found, page 1 of 1
Whole-genome sequencing as a tool for studying the microevolution of drug-resis...
Diniz, Jaciara; von Groll, Andrea; Unis, Gisela; Dalla-Costa, Elis Regina; Rosa Rossetti, Maria Lúcia; Vianna, Júlia Silveira; Ramos, Daniela FernandesTreatment of drug-resistant tuberculosis requires extended use of more toxic and less effective drugs and may result in retreatment cases due to failure, abandonment or disease recurrence. It is therefore important to understand the evolutionary process of drug resistance in Mycobacterium tuberculosis. We here in describe the microevolution of drug resistance in serial isolates from six previously treated patie...
CPLP-TB: a new tuberculosis transnational surveillance tool for the lusophone c...
Perdigão, João; Silva, Carla; Diniz, Jaciara; Pereira, Catarina; Machado, Diana; Ramos, Jorge; Silva, Hugo; Abilleira, Fernanda; Brum, ClariceTuberculosis (TB) remains a major health problem within the Community of Portuguese Language Speaking Countries (CPLP). Despite the marked variation in TB incidence across its member-states and continued human migratory flux between countries, a considerable gap in the knowledge on the Mycobacterium tuberculosis population structure and strain circulation between the countries still exists. To address this, we ...
Clonal expansion across the seas as seen through CPLP-TB database: A joint effor...
Perdigão, João; Silva, Carla; Diniz, Jaciara; Pereira, Catarina; Machado, Diana; Ramos, Jorge; Silva, Hugo; Abilleira, Fernanda; Brum, ClariceTuberculosis (TB) remains a major health problem within the Community of Portuguese Language Speaking Countries (CPLP). Despite the marked variation in TB incidence across its member-states and continued human migratory flux between countries, a considerable gap in the knowledge on the Mycobacterium tuberculosis population structure and strain circulation between the countries still exists. To address this, we ...
Mycobacterium tuberculosis genetic diversity and drug resistance across Portugu...
Perdigão, João; Silva, Carla; Diniz, Jaciara; Pereira, Catarina; Machado, Diana; Ramos, Jorge; Silva, Hugo; Abilleira, Fernanda; Brum, ClariceBackground: Tuberculosis (TB) remains a major health problem within the Community of Portuguese Language Speaking Countries (CPLP). Despite the marked variation in TB incidence across its member-states and continued human migratory flux between countries, a considerable gap in the knowledge on the Mycobacterium tuberculosis population structure and strain circulation between the countries still exists. Material...
Clonal expansion across the seas as seen through CPLP-TB database: a joint effo...
Perdigão, João; Silva, Carla; Diniz, Jaciara; Pereira, Catarina; Machado, Diana; Ramos, Jorge; Silva, Hugo; Abilleira, Fernanda; Brum, ClariceTuberculosis (TB) remains a major health problem within the Community of Portuguese Language Speaking Countries (CPLP). Despite the marked variation in TB incidence across its member-states and continued human migratory flux between countries, a considerable gap in the knowledge on the Mycobacterium tuberculosis population structure and strain circulation between the countries still exists. To address this, we ...
Extrapulmonary TB or sarcoidosis associated with TB? Case report
Costa, Gabriel Domingues; Oliveira, Daniele Tailla; Almeida, Guilherme Brandão; Pacheco Pereira, Hugo Cataud; da Silva, Ana Barbara ScholanteObjectives: The present report aims to discuss the differential diagnosis between tuberculosis and sarcoidosis. Case description: The case of a 25-year-old male patient who developed granulomatous arthritis and osteomyelitis with nonnecrotizing granulomatous inflammation suggesting a sarcoidosis. Twenty-four months before this report, he had positive laboratory results to pulmonary tuberculosis, however, he was...
Tuberculosis across the seas: CPLP-TB - a joint effort in cataloguing mycobacte...
Perdigão, João; Silva, Carla; Diniz, Jaciara; Pereira, Catarina; Machado, Diana; Ramos, Jorge; da Silva, Fernanda; Brum, Clarice; Reis, Ana J.The Community of Portuguese Language Speaking Countries (CPLP) comprises nine countries across four continents, accounting for 7.2% of the world’s land area, and where tuberculosis (TB) is still a cause of public health concern. A marked variation in TB incidence (23 to 551 cases per 100 000 habitants) can be observed across the different member-states and, despite of this, a considerable gap in the knowledge o...