4 documents found, page 1 of 1
Vaccine breakthrough hypoxemic COVID-19 pneumonia in patients with auto-Abs neu...
Bastard, Paul; Vazquez, Sara E.; Liu, Jamin; Laurie, Matthew T.; Wang, Chung Yu; Gervais, Adrian; Le Voyer, Tom; Bizien, Lucy; Zamecnik, ColinLife-threatening "breakthrough" cases of critical COVID-19 are attributed to poor or waning antibody (Ab) response to SARS-CoV-2 vaccines in individuals already at risk. Preexisting auto-Abs neutralizing type I IFNs underlie at least 15% of critical COVID-19 pneumonia cases in unvaccinated individuals; their contribution to hypoxemic breakthrough cases in vaccinated people is unknown. We studied a cohort of 48 ...
Clinical spectrum and outcome of treatment for autoimmune cytopenias in rag def...
Foldvari, Zsofia; Ujhazi, Boglarka; Abolhassani, Hassan; Abraham, Roshini; Adeli, Mehdi; Aghamohammadi, Asghar; Al-Herz, Waleed; Assaf-Casals, AiaUniv Debrecen, Fac Med, Dept Immunol, Debrecen, Hungary; Harvard Univ, Massachusetts Gen Hosp, Sch Med, Pediat Allergy & Immunol, Boston, MA USA; Harvard Univ, Massachusetts Gen Hosp, Sch Med, Ctr Immunol & Inflammatory Dis, Boston, MA USA; Massachusetts Gen Hosp Children, Div Pediat Allergy Immunol, Boston, MA USA; Univ Tehran Med Sci, Childrens Med Ctr, Pediat Ctr Excellence, Res Ctr Immunodeficiencies, Tehra...
A three-dimensional model of human lung development and disease from pluripoten...
Chen, Ya-Wen; Huang, Sarah Xuelian; de Carvalho, Ana Luisa Rodrigues Toste; Ho, Siu-Hong; Islam, Mohammad Naimul; Volpi, Stefano; Notarangelo, Luigi D.Recapitulation of lung development from human pluripotent stem cells (hPSCs) in three dimensions (3D) would allow deeper insight into human development, as well as the development of innovative strategies for disease modelling, drug discovery and regenerative medicine. We report here the generation from hPSCs of lung bud organoids (LBOs) that contain mesoderm and pulmonary endoderm and develop into branching ai...
Broad-spectrum antibodies against self-antigens and cytokines in RAG deficiency
Notarangelo, Luigi D.