31 documents found, page 1 of 4
Development of dual-crosslinked Pluronic F127/Chitosan injectable hydrogels inc...
Pouso, Manuel António do Rosário; Melo, Bruna L.; Gonçalves, Joaquim; Mendonça, António; Correia, I.J.; Diogo, Duarte de MeloNanomaterials with responsiveness to near-infrared light can mediate the photoablation of cancer cells with an exceptional spatio-temporal resolution. However, the therapeutic outcome of this modality is limited by the nanostructures’ poor tumor uptake. To address this bottleneck, it is appealing to develop injectable in situ forming hydrogels due to their capacity to perform a tumor-confined delivery of the na...
Simple preparation of POxylated nanomaterials for cancer chemo-PDT/PTT
Nave, Micaela; Costa, Francisco J. P.; Alves, Cátia; Sousa, Rita Lima; Melo, Bruna L.; Correia, I.J.; Diogo, Duarte de MeloNear infrared (NIR) light-responsive nanomaterials hold potential to mediate combinatorial therapies targeting several cancer hallmarks. When irradiated, these nanomaterials produce reactive oxygen species (photodynamic therapy) and/or a temperature increase (photothermal therapy). These events can damage cancer cells and trigger the release of drugs from the nanomaterials’ core. However, engineering nanomateri...
Development of Thiol-Maleimide hydrogels incorporating graphene-based nanomater...
Costa, Francisco J. P.; Nave, Micaela; Sousa, Rita Lima; Alves, Cátia; Melo, Bruna L.; Correia, I.J.; Diogo, Duarte de MeloNano-sized materials have been widely explored in the biomedicine field, especially due to their ability to encapsulate drugs intended to be delivered to cancer cells. However, systemically administered nanomaterials face several barriers that can hinder their tumor-homing capacity. In this way, researchers are now focusing their efforts in developing technologies that can deliver the nanoparticles directly int...
Chitosan-based injectable in situ forming hydrogels containing dopamine-reduced...
Melo, Bruna L.; Sousa, Rita Lima; Alves, Cátia; Moreira, André F.; Correia, I.J.; Diogo, Duarte de MeloStrategies combining nanomaterials’ chemotherapy and photothermal therapy hold an enormous potential for improving cancer treatment. Still, the translation of this modality has been hindered by the immunogenicity triggered by some of the polymers used for coating nanomaterials as well as by the nanostructures’ poor tumor uptake after systemic administration. To address this bottleneck, the formulation of inject...
Cell‐Derived Vesicles for Nanoparticles' Coating: Biomimetic Approaches for Enh...
Rodrigues, Ana Carolina Félix; Fernandes, Natanael; Diogo, Duarte de Melo; Correia, I.J.; Moreira, André F.Cancer nanomedicines are designed to encapsulate different therapeuticagents, prevent their premature release, and deliver them specifically tocancer cells, due to their ability to preferentially accumulate in tumor tissue.However, after intravenous administration, nanoparticles immediatelyinteract with biological components that facilitate their recognition by theimmune system, being rapidly removed from circu...
Chitin- and chitosan-based strategies in wound healing
Cabral, Cátia S. D.; Graça, Mariana F. P.; Moreira, André F.; Diogo, Duarte de Melo; Correia, I.J.Nowadays, chronic wounds are still a huge health problem with a high impact on the patients’ quality of life. In this way, the development of an ideal wound dressing is of utmost importance. To accomplish that, researchers have been using natural polymers to produce new types of dressings, that can activate/direct specific cellular responses, leading to an improved healing process. Among the natural polymers, c...
Metal-Polymer Nanoconjugates Application in Cancer Imaging and Therapy
Figueiredo, André Q.; Rodrigues, Ana Carolina Félix; Fernandes, Natanael; Diogo, Duarte de Melo; Correia, I.J.; Moreira, AndréMetallic-based nanoparticles present a unique set of physicochemical properties that support their application in different fields, such as electronics, medical diagnostics, and therapeutics. Particularly, in cancer therapy, the plasmonic resonance, magnetic behavior, X-ray attenuation, and radical oxygen species generation capacity displayed by metallic nanoparticles make them highly promising theragnostic sol...
Heptamethine Cyanine-Loaded Nanomaterials for Cancer Immuno-Photothermal/Photod...
Alves, Cátia; Sousa, Ana Rita Lima; Melo, Bruna L.; Moreira, André F.; Correia, I.J.; Diogo, Duarte de MeloThe development of strategies capable of eliminating metastasized cancer cells and preventing tumor recurrence is an exciting and extremely important area of research. In this regard, therapeutic approaches that explore the synergies between nanomaterial-mediated phototherapies and immunostimulants/immune checkpoint inhibitors have been yielding remarkable results in pre-clinical cancer models. These nanomateri...
HA/PEI-coated acridine orange-loaded gold-core silica shell nanorods for cancer...
Rodrigues, Ana Carolina Félix; Fernandes, Natanael; Diogo, Duarte de Melo; Ferreira, Paula; Correia, I.J.; Moreira, AndréAims: To develop a tumor-targeted chemo-photothermal nanomedicine through the functionalization of acridine orange (AO)-loaded gold-core mesoporous silica shell (AuMSS) nanorods with polyethylenimine (PEI) and hyaluronic acid (HA). Methods: Functionalization of the AuMSS nanorods was achieved through the chemical linkage of PEI followed by electrostatic adsorption of HA. Results: HA functionalization improved A...
Poly(2-ethyl-2-oxazoline) functionalized reduced graphene oxide: Optimization o...
Sousa, Ana Rita Lima; Alves, Cátia; Melo, Bruna L.; Moreira, André; Mendonça, António; Correia, I.J.; Diogo, Duarte de MeloThe high near infrared (NIR) absorption displayed by reduced graphene oxide (rGO) nanostructures renders them a great potential for application in cancer photothermal therapy. However, the production of this material often relies on the use of hydrazine as a reductant, leading to poor biocompatibility and environmental-related issues. In addition, to improve rGO colloidal stability, this material has been funct...