3 documents found, page 1 of 1
Molecular Pathways and Mechanisms in the Biogenesis of Influenza A Virus Matrix...
Diwo, Christian"Membrane protein biogenesis is an essential cellular process, ensuring the proper synthesis, targeting, and insertion of proteins into biological membranes. This thesis investigates the molecular mechanisms governing membrane protein biogenesis, with a particular focus on how the Influenza A Virus (IAV) hijacks host cellular pathways to support viral protein production. The study primarily explores the role of...
Challenges in imaging analyses of biomolecular condensates in cells infected wi...
Etibor, Temitope Akhigbe; O’Riain, Aidan; Alenquer, Marta; Diwo, Christian; Vale-Costa, Sílvia; Amorim, Maria JoãoBiomolecular condensates are crucial compartments within cells, relying on their material properties for function. They form and persist through weak, transient interactions, often undetectable by classical biochemical approaches. Hence, microscopy-based techniques have been the most reliable methods to detail the molecular mechanisms controlling their formation, material properties, and alterations, including ...
Population homogeneity for the antibody response to COVID-19 BNT162b2/Comirnaty...
Faro-Viana, João; Bergman, Marie-Louise; Gonçalves, Lígia A.; Duarte, Nadia; Coutinho, Teresa P.; Borges, Patricia C.; Diwo, Christian; Castro, RuteABSTRACT: While mRNA vaccines are administrated worldwide in an effort to contain the COVID-19 pandemic, the heterogeneity of the humoral immune response they induce at the population scale remains unclear. Here, in a prospective, longitudinal, cohort-study, including 1245 hospital care workers and 146 nursing home residents scheduled for BNT162b2 vaccination, together covering adult ages from 19 to 99 years, w...