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Surface engineering of silica nanoparticles for oral insulin delivery: characte...
Andreani, Tatiana; Kiill, Charlene P.; Souza, Ana Luiza R. de; Fangueiro, Joana F.; Fernandes, Lisete; Doktorovová, Slavomira; Santos, Dario L.The present work aimed at studying the interaction between insulin and SiNP surfaced with mucoadhesive polymers (chitosan, sodium alginate or polyethylene glycol) and the evaluation of their biocompatibility with HepG2 and Caco-2 cell lines, which mimic in vivo the target of insulin-loaded nanoparticles upon oral administration. Thus, a systematic physicochemical study of the surface-modified insulin-silica nan...
Date: 2014
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Origin: Estudo Geral - Universidade de Coimbra