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Renal artery stenosis in living donor kidney transplantation: a rare cause of “...
Dias, Bruno Fraga; Marques, Roberto; Faria, Vitória; Domingues, Patrícia; Ribeiro, Catarina; Silvano, José; Malheiro, Jorge; Almeida, ManuelaTransplant renal artery stenosis (TRAS) is a well-recognized vascular complication after kidney transplantation, with an incidence ranging from 1% to 23%. TRAS often presents with clinical features such as refractory hypertension, de novo hypertension, allograft dysfunction, and the presence of a bruit over the graft. A rare manifestation of TRAS is flash pulmonary edema. Here, we present a case of a 37-year-ol...
Análise de variantes no gene STK11 e sua influência na resposta à imunoterapia
Bessa, Ana; Pina, Maria; Domingues, Patrícia; Dias, Margarida; Pinto, Carla; Cirnes, Luís; Silva, Regina A.A imunoterapia é uma das ferramentas terapêuticas de sucesso usadas no tratamento do cancro de pulmão, contudo alguns doentes apresentam progressão da doença ou morte. O gene Serine/ threonineKinase 11 (STK11) está descrito como tendo um papel na fisiologia do sistema imune(SI) e que alterações genéticas no mesmo podem influenciar negativamente a resposta dos pacientes à imunoterapia. Estudar alterações genétic...
Assessment of the biofuel production potential from phytoremediation sunflower ...
Marques, Ana P. G. C.; Domingues, Patrícia; Prata, Nuno; Castro, P. M. L.; Caetano, N. S.There are presently more than 3 million contaminated sites all over EU, according to the EEA (report 25186 EN). Heavy metal contamination is of particular concern, as metals are not degradable. Phytoremediation is gaining attention from the public and is an attractive low cost alternative for soil requalification, by establishing a vegetation cover which will stabilize the site, avoiding dispersion of contamina...
Assessment of the biofuel production potential from phytoremediation sunflower ...
Marques, Ana P. G. C.; Domingues, Patrícia; Prata, Nuno; Caetano, Nídia S.; Castro, Paula M. L.There are presently more than 3 million contaminated sites all over EU, according to the EEA (report 25186 EN). Heavy metal contamination is of particular concern, as metals are not degradable. Phytoremediation is gaining attention from the public and is an attractive low cost alternative for soil requalification, by establishing a vegetation cover which will stabilize the site, avoiding dispersion of contamina...
Patterns of protein expression and cytogenetic alterations in meningiomas: rela...
Domingues, PatríciaTese de doutoramento em Ciências Farmacêuticas, apresentada à Faculdade de Farmácia da Universidade de Coimbra; Os meningiomas são tumores relativamente comuns do sistema nervoso central. Apesar de serem classificados maioritariamente como benignos/lesões de grau I segundo a OMS, numa percentagem significativa de casos ainda ocorre recidiva após cirurgia. Deste modo, continua a ser necessário identificar parâme...
Amplified and Homozygously Deleted Genes in Glioblastoma: Impact on Gene Expres...
Crespo, Inês; Tão, Hermínio; Nieto, Ana Belen; Rebelo, Olinda; Domingues, Patrícia; Vital, Ana Luísa; Patino, Maria del Carmen; Barbosa, MarcosBackground: Glioblastoma multiforme (GBM) displays multiple amplicons and homozygous deletions that involve relevant pathogenic genes and other genes whose role remains unknown. Methodology: Single-nucleotide polymorphism (SNP)-arrays were used to determine the frequency of recurrent amplicons and homozygous deletions in GBM (n = 46), and to evaluate the impact of copy number alterations (CNA) on mRNA levels of...