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Grape stems as sources of tryptophan and selenium: functional properties and an...

Fernandes, Raquel; Medrano-Padial, Concepción; Dias-Costa, Rui; Domínguez-Perles, Raúl; Botelho, C. M.; Fernandes, Rúben; Barros, Ana Novo

The Douro Demarcated Region's winery industry produces million tonnes of by-products annually, making their reuse essential to minimize environmental impact. Grape stems, rich in bioactive compounds and nutrients, have demonstrated potential health benefits. This study analysed four red grape stems from the Douro region to assess their nutritional value and potential health benefit. Tryptophan, selenium, and ph...


Overview of polyphenolic composition and related biological activities of grape...

Dias-Costa, Rui; Coelho, Marta; Domínguez-Perles, Raúl; Gouvinhas, Irene; Barros, Ana Novo

Grape stems, or stalks, are lignocellulosic by-products removed during the destemming process to reduce astringency in wine production. These by-products are a notable source of minerals and polyphenolic compounds, such as phenolic acids, stilbenes, proanthocyanidins and catechin derivatives, flavonols, flavones, and anthocyanins. These bioactive compounds have been associated with several beneficial effects on...


Structural/Functional Matches and Divergences of Phytoprostanes and Phytofurans...

Medina, Sonia; Gil-Izquierdo, Angel; Durand, Thierry; Ferreres, Federico; Domínguez-Perles, Raúl

Structure-activity relationship (SAR) constitutes a crucial topic to discover new bioactive molecules. This approach initiates with the comparison of a target candidate with a molecule or a collection of molecules and their attributed biological functions to shed some light in the details of one or more SARs and subsequently using that information to outline valuable application of the newly identified compound...


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