3 documents found, page 1 of 1
From Light Chain Deposition to Multiple Myeloma - Case Report and Literature Re...
Domingos, A; Vidinha, J; Guedes, A; Macedo, A; Góis, M; Leão Neves, PMonoclonal gammopathies consist of a broad spectrum of diseases, ranging from asymptomatic monoclonal gammopathy of undetermined significance to multiple myeloma (MM). Multiple myeloma is a malignant plasma cell disorder and accounts for 10% of all hematological malignancies and 1% of all malignancies. Differential diagnosis may be challenging, considering the variety of clinical entities with similar behavior....
Design, synthesis and stability of N-acyloxymethyl- and N-aminocarbonyloxymethy...
Clemente, A; Domingos, A; Grancho, AP; Iley, J; Moreira, R; Neres, J; Palma, N; Santana, AB; Valente, EA series of N-acyloxymethyl- and N-aminocarbonyloxymethyl derivatives of 2-azetidinones. 3, with different substituent patterns at the beta -lactam C-3 and C-4 positions, were designed as potential mechanism-based inhibitors for human leukocyte elastase and found to exhibit inhibitory potency and selectivity for the enzyme, (C) 2001 Elsevier Science Ltd. All rights reserved.
N-Acyloxymethyl-2-azetidinones as Human Leukocyte Elastase Inhibitors
Santana, AB; Valente, E; Neres, J; Moreira, R; Palma, N; Grancho, AP; Domingos, A; Clemente, A; Iley, J