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ER-mediated stress induces mitochondrial-dependent caspases activation in NT2 n...
Arduíno, Daniela M.; Esteves, A. Raquel; Domingues, A. Filipa; Pereira, Cláudia M. F.; Cardoso, Sandra M.; Oliveira, C. R.Recent studies have revealed that endoplasmic reticulum (ER) disturbance is involved in the pathophysiology of neurodegenerative disorders, contributing to the activation of the ER stress-mediated apoptotic pathway. Therefore, we investigated here the molecular mechanisms underlying the ER-mitochondria axis, focusing on calcium as a potential mediator of cell death signals. Using NT2 cells treated with brefeldi...
Date: 2009
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Origin: Estudo Geral - Universidade de Coimbra