6 documents found, page 1 of 1
Práticas de Ciência Aberta e Gestão de Dados de Investigação na Universidade de...
Domingues, Catarina; Carvalho, Ana dos Santos; Noro, JorgeConhecer o panorama nacional ao nível das Instituições de Ensino Superior (IES), no que diz respeito às boas práticas de Ciência Aberta e Gestão de Dados de Investigação (GDI), constitui uma premissa fundamental para a correta dinamização destas temáticas nos ecossistemas de Investigação e Ensino Superior do nosso país. Para esse efeito, durante o mês de setembro de 2023, o Grupo de Trabalho do Fórum GDI dedica...
Open Science Community Coimbra: cocriação do plano mestre
Almeida, Inês A. T.; Miguéis, Ana Eva; Santos-Carvalho, Ana; Direito, Bruno; Domingues, Catarina; Santos, Joaquim; Noro, Jorge; Ferreira, LicíniaA Ciência Aberta (CA) envolve um conjunto de princípios e práticas que permite que os diferentes resultados da investigação se tornem mais acessíveis, transparentes, fiáveis e inclusivos, aumentando a qualidade de produção de conhecimento, a reutilização dos resultados e o impacto na sociedade. A adoção de princípios e práticas da CA implica uma profunda mudança cultural particularmente difícil de implementar n...
Cofilin-1 Is a Mechanosensitive Regulator of Transcription
Domingues, Catarina; Geraldo, A. Margarida; Anjo, Sandra I.; Matos, André; Almeida, Cláudio; Caramelo, Inês; Lopes-da-Silva, José A; Paiva, ArturThe mechanical properties of the extracellular environment are interrogated by cells and integrated through mechanotransduction. Many cellular processes depend on actomyosin-dependent contractility, which is influenced by the microenvironment's stiffness. Here, we explored the influence of substrate stiffness on the proteome of proliferating undifferentiated human umbilical cord-matrix mesenchymal stem/stromal ...
Cofilin-1 is a mechanosensitive regulator of transcription
Domingues, Catarina; Geraldo, A Margarida; Anjo, Sandra Isabel; Matos, André; Almeida, Cláudio; Caramelo, Inês; Lopes-da-Silva, José A; Paiva, ArturThe mechanical properties of the extracellular environment are interrogated by cells and integrated through mechanotransduction. Many cellular processes depend on actomyosin-dependent contractility, which is influenced by the microenvironment's stiffness. Here, we explored the influence of substrate stiffness on the proteome of proliferating undifferentiated human umbilical cord-matrix mesenchymal stem/stromal ...
Subacute effects of the thiodicarb pesticide on target organs of male wistar ra...
Dias, Elsa; Gomes, Mariana; Domingues, Catarina; Ramalheira, Elmano; Morais, Simone; Pereira, Maria de LourdesThiodicarb, a carbamate pesticide widely used on crops, may pose several environmental and health concerns. This study aimed to explore its toxicological profile on male rats using hematological, biochemical, histopathological, and flow cytometry markers. Exposed animals were dosed daily at 10, 20, or 40 mg/kg/body weight (group A, B, and C, respectively) during 30 d. No significant changes were observed in hem...
Subacute Effects of the Thiodicarb Pesticide on Target Organs of Male Wistar Ra...
Dias, Elsa; Gomes, Mariana; Domingues, Catarina; Ramalheira, Elmano; Morais, Simone; Pereira, Maria de LourdesThiodicarb, a carbamate pesticide widely used on crops, may pose several environmental and health concerns. This study aimed to explore its toxicological profile on male rats using hematological, biochemical, histopathological, and flow cytometry markers. Exposed animals were dosed daily at 10, 20, or 40 mg/kg/body weight (group A, B, and C, respectively) during 30 d. No significant changes were observed in hem...