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Errors in protein synthesis increase the level of saturated fatty acids and aff...

Araújo, A; Melo, T; Maciel, E; Pereira, C; Morais, C; Santinha, D; Tavares, J; Oliveira, H; Jurado, A; Costa, V; Domingues, P; Domingues, M; Santos, M

The occurrence of protein synthesis errors (mistranslation) above the typical mean mistranslation level of 10−4 is mostly deleterious to yeast, zebrafish and mammal cells. Previous yeast studies have shown that mistranslation affects fitness and deregulates genes related to lipid metabolism, but there is no experimental proof that such errors alter yeast lipid profiles. We engineered yeast strains to misincorpo...


Celulite Orbitária Pré e Pós-Septal em Idade Pediátrica: 17 Anos de Experiência

Domingues, M; Luís, C; Brito, MJ; Correia, P

Introdução: A celulite orbitária, pré e pós-septal, é a principal infeção dos tecidos e anexos do olho, tendo diferentes abordagens e implicações clínicas. Métodos: Análise retrospectiva de crianças internadas num hospital de nível II da região metropolitana de Lisboa por celulite orbitária ao longo de 17 anos. Comparação entre celulite pré-septal e infeção pós-septal no que respeita à sua apresentação clínica,...


Pediatric ocular rosacea, a misdiagnosed disease with high morbidity: Proposed ...

Arriaga, C; Domingues, M; Castela, G; Salgado, M

Ocular rosacea is an important and underdiagnosed chronic inflammatory disorder observed in children. A clinical spectrum ranging from chronic eyelid inflammation, recurrent ocular redness, photophobia and/or hordeola/chalazions and conjunctival/corneal phlyctenules evolving to neovascularization and scarring may occur. Visual impairment and consequent amblyopia are frequent and corneal perforation although rar...


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