14 documents found, page 1 of 2
Mapping and Analysis of Public Policies for Active Aging in EUROACE | Euroregio...
Baltazar, Maria da Saudade; Domingues, Marco; Domínguez-Párraga, LídiaThis study compares public policies and programmes promoting active ageing between Extremadura (Spain) and the Alentejo and Centro (Portugal) regions within the EUROACE area. The aim is to map and analyse initiatives, identify trends, participation mechanisms and innovation factors to improve the quality of life of older people. The research uses an exploratory approach with qualitative data analysis. A sample ...
Activity modulation of the Escherichia coli F1FO ATP synthase by a designed ant...
Makowski, Marcin; Almendro-Vedia, Víctor G.; Domingues, Marco; Franco, Octavio L.; López-Montero, Iván; Melo, Manuel N.; Santos, Nuno C.Most antimicrobial peptides (AMPs) exert their microbicidal activity through membrane permeabilization. The designed AMP EcDBS1R4 has a cryptic mechanism of action involving the membrane hyperpolarization of Escherichia coli, suggesting that EcDBS1R4 may hinder processes involved in membrane potential dissipation. We show that EcDBS1R4 can sequester cardiolipin, a phospholipid that interacts with several respir...
3iCubing: An Interval Inverted Index Approach to Data Cubes
Domingues, Marco; Silva, Rodrigo Rocha; Bernardino, JorgeThe increase in the amounts of information used to analyze data is problematic since the memory necessary to store and process it is getting quite big. The interval inverted index representation was developed to reduce the required memory to store data, and Frag-Cubing is one of the most popular algorithms. In this paper, we propose two new data cubing algorithms: 3iCubing and M3iCubing. 3iCubing is a Frag-Cubi...
Reacendimentos em Viana do Castelo - O problema da causa ou a causa do problema?
Domingues, MarcoViana do Castelo é o distrito com maior taxa de reacendimentos do país, em 2020 são 13% as ocorrências que após processo de investigação é apurado serem resultantes de reacendimento de um incêndio anterior. O total dos 91 “supostos” reacendimentos apresentam uma área ardida de 114,25 hectares, mas independentemente da área, é o desempenho das entidades envolvidas em todo o processo que acaba por ser colocado em...
25-hydroxycholesterol effect on membrane structure and mechanical properties
Domingues, Marco; Gomes, Bárbara; Hollmann, Axel; Santos, Nuno C.Cholesterol is responsible for the plasticity of plasma membranes and is involved in physiological and pathophysiological responses. Cholesterol homeostasis is regulated by oxysterols, such as 25-hydroxycholesterol. The presence of 25-hydroxycholesterol at the membrane level has been shown to interfere with several viruses' entry into their target cells. We used atomic force microscopy to assess the effect of 2...
Lipid membrane-based therapeutics and diagnostics
Carvalho, Patricia; Makowski, Marcin; Domingues, Marco; Martins, Ivo C.; Santos, Nuno C.Success rates in drug discovery are extremely low, and the imbalance between new drugs entering clinical research and their approval is steadily widening. Among the causes of the failure of new therapeutic agents are the lack of safety and insufficient efficacy. On the other hand, timely disease diagnosis may enable an early management of the disease, generally leading to better and less costly outcomes. Severa...
Mechanistic insights into the leishmanicidal and bactericidal activities of Bat...
Dematei, Anderson; Nunes, João B.; Moreira, Daniel C.; Jesus, Jéssica A.; Laurenti, Márcia D.; Mengarda, Ana C. A.; Vieira, Maria SilvaSnake venoms are important sources of bioactive molecules, including those with antiparasitic activity. Cathelicidins form a class of such molecules, which are produced by a variety of organisms. Batroxicidin (BatxC) is a cathelicidin found in the venom of the common lancehead (Bothrops atrox). In the present work, BatxC and two synthetic analogues, BatxC(C-2.15Phe) and BatxC(C-2.14Phe)des-Phe1, were assessed f...
Os desafios das respostas sociais de apoio a pessoas idosas face à pandemia COV...
Domingues, Marco; Vieira, Regina Ferreira; Candeias, MarisaOs assistentes sociais (adiante designados por AS), especialmente os que desempenham funções de gestão e administração social de equipamentos sociais, assumem uma enorme responsabilidade nas organizações de economia social prestadoras de serviços sociais, atuando ao nível micro e meso, participando na tomada de decisões do foro organizacional. Na resposta às exigências quotidianas, o seu agir profissional é emp...
Enfuvirtide-protoporphyrin IX dual-loaded liposomes: in vitro evidence of syner...
Figueira, Tiago Nascimento; Domingues, Marco; Illien, Françoise; Cadima Couto, Carla Iris; Todorovski, Toni; Andreu, David; Sagan, SandrineWe have developed a nanocarrier consisting of large unilamellar vesicles (LUVs) for combined delivery of two human immunodeficiency virus type 1 (HIV-1) entry inhibitors, enfuvirtide (ENF) and protoporphyrin IX (PPIX). The intrinsic lipophilicity of ENF and PPIX, a fusion inhibitor and an attachment inhibitor, respectively, leads to their spontaneous incorporation into the lipid bilayer of the LUVs nanocarrier....
Application of light scattering techniques to nanoparticle characterization and...
Carvalho, Patricia; Felício, Mário Romão; Santos, Nuno C.; Abreu, Sónia Gonçalves; Domingues, MarcoOver the years, the scientific importance of nanoparticles for biomedical applications has increased. The high stability and biocompatibility, together with the low toxicity of the nanoparticles developed lead to their use as targeted drug delivery systems, bioimaging systems, and biosensors. The wide range of nanoparticles size, from 10 nm to 1 μm, as well as their optical properties, allow them to be studied ...