2 documents found, page 1 of 1
Inhibition of indoleamine 2,3-dioxygenase prevented cognitive impairment in adu...
Vilela, Márcia Carvalho; Barichello, Tatiana; Generoso, Jaqueline S.; Simões, Lutiana R.; Elias, Samuel G.; Tashiro, Michael H.; Dominguini, DiogoStreptococcus pneumoniae is a common cause of forms of bacterial meningitis that have a high mortality rate and cause long-term neurologic sequelae. We evaluated the effects of an indoleamine 2,3-dioxygenase (IDO) inhibitor on proinflammatory mediators and memory in Wistar rats subjected to pneumococcal meningitis. The animals were divided into 4 groups: sham, sham treated with IDO inhibitor, meningitis, and me...
Neonatal Escherichia coli K1 meningitis causes learning and memory impairments ...
Vilela, Márcia Carvalho; Barichello, Tatiana; Dagostim, Valdemira S.; Generoso, Jaqueline S.; Simões, Lutiana R.; Dominguini, Diogo; Silvestre, CintiaNeonatal Escherichia coli meningitis continues to be an important cause of mortality and morbidity in newborns worldwide. The aim of this study was to investigate the cytokines/chemokines, brain-derived neurotrophic factor (BDNF) levels, blood–brain barrier integrity in neonatal rats following E. coli K1 experimental meningitis infection and subsequent behavioural parameters in adulthood. In the hippocampus, in...