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The impact of 25-hydroxyvitamin D and calcium on risk of age-related macular de...

Dong, Xing-Xuan; Chen, Dong-Ling; Miao, Yi-Fan; Li, Dan-Lin; Kai, Jia-Yan; Hu, Dan-Ning; Zhang, Xiao-Feng; Lança, Carla; Andrzej, Grzybowski

Background: The relationships between 25-hydroxyvitamin D [25(OH)D] and calcium and age-related macular degeneration (AMD) are unclear. Objectives: This study aimed to investigate the causal role of 25(OH)D concentrations, calcium concentrations, and dietary supplements use of vitamin D and calcium on the risk of AMD and its subtypes. Methods: Independent genetic variants associated with 25(OH)D and calcium con...


Association between ambient air pollution and dry eye symptoms among Chinese in...

Kai, Jia-Yan; Wu, Yi-Bo; Dong, Xing-Xuan; Miao, Yi-Fan; Li, Dan-Lin; Hu, Dan-Ning; Lança, Carla; Grzybowski, Andrzej; Pan, Chen-Wei

Purpose: To examine the association between ambient air pollution and dry eye symptoms (DES) during the COVID-19 pandemic and explore whether air pollution had increased the risk of DES to a greater extent than other risk factors. Methods: A nationwide cross-sectional survey was conducted from June 20, 2022 to August 31, 2022. The Ocular Surface Disease Index-6 (OSDI-6) questionnaire was used to assess the pres...


Association of sleep traits with myopia in children and adolescents: a meta-ana...

Dong, Xing-Xuan; Xie, Jia-Yu; Li, Dan-Lin; Dong, Yi; Zhang, Xiao-Feng; Lança, Carla; Grzybowski, Andrzej; Pan, Chen-Wei

Purpose: The association between sleep and myopia in children and adolescents has been reported, yet it remains controversial and inconclusive. This study aimed to investigate the influence of different sleep traits on the risk of myopia using meta-analytical and Mendelian randomization (MR) techniques. Methods: The literature search was performed on August 31, 2023, based on PubMed, Embase, Web of Science, and...


Lower indoor spatial frequency increases the risk of myopia in children

Li, Dan-Lin; Dong, Xing-Xuan; Yang, Jin-Liu-Xing; Lança, Carla; Grzybowski, Andrzej; Pan, Chen-Wei

Background/aims: Animal models have shown that the absence of high-frequency visual information can precipitate the onset of myopia, but this relationship remains unclear in humans. This study aims to explore the association between the spatial frequency content of the visual environment and myopia in children. Methods: Images from the rooms of children and their frequently visited outdoor areas were taken by t...


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