8 documents found, page 1 of 1
Population mobility and the changing epidemics of HIV-2 in Portugal
Carvalho, A; Valadas, E; França, L; Carvalho, C; Aleixo, M; Mendez, J; Marques, R; Sarmento, A; Doroana, M; Antunes, F; Branco, T; Águas, M; Castro, RINTRODUCTION: Portugal is the European country with the highest frequency of HIV-2 infection, which is mainly concentrated in West Africa. The cumulative number of notified HIV-2 infections in Portugal was 1813 by the end of December 2008. To better characterize the dynamics of HIV-2 infection in the country and to obtain data that may be of use in the prevention of the spread of HIV-2, we evaluated a large poo...
Baseline Susceptibility of Primary HIV-2 to Entry Inhibitors
Borrego, P; Calado, R; Marcelino, JM; Bártolo, I; Rocha, C; Cavaco-Silva, P; Doroana, M; Antunes, F; Maltez, F; Caixas, U; Barroso, H; Taveira, NBACKGROUND: The baseline susceptibility of primary HIV-2 to maraviroc (MVC) and other entry inhibitors is currently unknown. METHODS: The susceptibility of 19 HIV-2 isolates obtained from asymptomatic and AIDS patients and seven HIV-1 clinical isolates to the fusion inhibitors enfuvirtide (ENF) and T-1249, and to the coreceptor antagonists AMD3100, TAK-779 and MVC, was measured using a TZM-bl cell-based assay. ...
Population mobility and the changing epidemics of HIV-2 in Portugal
Carvalho, AC; Valadas, E; França, L; Carvalho, C; Aleixo, MJ; Mendez, J; Marques, R; Sarmento, A; Doroana, M; Antunes, F; Branco, T; Águas, MIntroduction: Portugal is the European country with the highest frequency of HIV-2 infection, which is mainly concentrated in West Africa. The cumulative number of notified HIV-2 infections in Portugal was 1813 by the end of December 2008. To better characterize the dynamics of HIV-2 infection in the country and to obtain data that may be of use in the prevention of the spread of HIV-2, we evaluated a large poo...
Recent advances in antiretroviral treatment and prevention in HIV-infected pati...
Maltez, F; Doroana, M; Branco, T; Valente, CPURPOSE OF REVIEW: To discuss new antiretroviral agents (ARVs) and alternative ARV treatment strategies that are currently being evaluated, and to provide an overview of the most recent advances in HIV vaccine development. RECENT FINDINGS: There is a continuous need for improvements in ARV therapy (ART) and several new ARVs are currently undergoing clinical investigation, including the non-nucleoside reverse tr...
The Role of the Humoral Immune Response in the Molecular Evolution of the Envel...
Borrego, P; Marcelino, JM; Rocha, C; Doroana, M; Antunes, F; Maltez, F; Gomes, P; Novo, C; Barroso, H; Taveira, NBACKGROUND: This study was designed to investigate, for the first time, the short-term molecular evolution of the HIV-2 C2, V3 and C3 envelope regions and its association with the immune response. Clonal sequences of the env C2V3C3 region were obtained from a cohort of eighteen HIV-2 chronically infected patients followed prospectively during 2-4 years. Genetic diversity, divergence, positive selection and glyc...
Cerebral toxoplasmosis in AIDS patients, CT and MRI images and differential dia...
Miguel, J; Champalimaud, J L; Borges, A; Chorão, M; Branco, G; Doroana, M; Medina, ECranial computed-tomographies (CT) and magnetic resonance imaging (MRI) of 14 patients with AIDS and central nervous system toxoplasmosis (CNST) were reviewed. In spite of the low specificity of CT and MRI findings in CNS mass lesions of AIDS patients, there are some features which have been observed as more typical of CNST, namely: 94.9% of the lesions were round shaped and 94.5% had ring or nodular enhancemen...
Febrile coma and disseminated intravascular coagulation following heat stroke.
Lélis, M; do Carmo, G; Caldeira, L; Abreu, J; Freitas, L; Doroana, MA clinical case that occurred in a 42 years old female and which fulfils the diagnostic criteria for the entity described as Heat Stroke is presented. In this case, besides the usual manifestations of hyperpyrexia without sweating along with consciousness disorders, features of consumptive coagulopathy, rhabdomyolysis and well marked laboratory liver dysfunction have also been found. The severity of this situat...
Emphysematous cholecystitis.
Freitas, L; Do Carmo, G; Caldeira, L; Farto e Abreu, J; Lélis, M; Doroana, MEmphysematous cholecystitis (EC) is a rare and dramatic disease that requires prompt therapeutic procedures. The authors report a case of a 70-year-old-woman, admitted to the Intensive Care Unit for Infectious Diseases of the Santa Maria Hospital, with the diagnosis of EC. The literature on EC is also reviewed.; Emphysematous cholecystitis (EC) is a rare and dramatic disease that requires prompt therapeutic pro...