2 documents found, page 1 of 1
Umbilical-Cord-Derived Mesenchymal Stromal Cells Modulate 26 Out of 41 T Cell S...
Laranjeira, Paula; Dos Santos, Francisco; Salvador, Maria João; Simões, Irina N.; Cardoso, Carla M. P.; Silva, Bárbara M.; Henriques-Antunes, HelenaSystemic sclerosis (SSc) is an immune-mediated disease wherein T cells are particularly implicated, presenting a poor prognosis and limited therapeutic options. Thus, mesenchymal-stem/stromal-cell (MSC)-based therapies can be of great benefit to SSc patients given their immunomodulatory, anti-fibrotic, and pro-angiogenic potential, which is associated with low toxicity. In this study, peripheral blood mononucle...
Human Bone Marrow Mesenchymal Stromal/Stem Cells Regulate the Proinflammatory R...
Laranjeira, Paula; Pedrosa, Mónia; Duarte, Cátia; Pedreiro, Susana; Antunes, Brígida; Ribeiro, Tânia; Dos Santos, Francisco; Martinho, AntónioRheumatoid arthritis (RA) is a disabling autoimmune disease whose treatment is ineffective for one-third of patients. Thus, the immunomodulatory potential of mesenchymal stromal/stem cells (MSCs) makes MSC-based therapy a promising approach to RA. This study aimed to explore the immunomodulatory action of human bone marrow (BM)-MSCs on myeloid dendritic cells (mDCs) and monocytes, especially on cytokines/chemok...