9 documents found, page 1 of 1
Sensitivity to change of structural outcomes in axial spondyloarthritis after 1...
López-Medina, Clementina; Molto, Anna; Sepriano, Alexandre; Ramiro, Sofia; Tournadre, Anne; Dougados, Maxime© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.; OBJECTIVE: To evaluate the sensitivity to change in structural imaging outcomes over 10 years of follow-up in patients with axial spondyloarthritis (axSpA). METHODS: Patients with axSpA from the Devenir des Spondyloarthropathies Indifferénciées Récentes cohort were inclu...
Which imaging outcomes for axSpA are most sensitive to change?
Sepriano, Alexandre; Ramiro, Sofia; van der Heijde, Désirée; Dougados, Maxime; Claudepierre, Pascal; Feydy, Antoine; Reijnierse, MoniqueOBJECTIVE: To compare the sensitivity to change of different imaging scoring methods in patients with early axial spondyloarthritis (axSpA). METHODS: Patients from the DESIR cohort fulfilling the ASAS axSpA criteria were included. Radiographs and MRI of the sacroiliac joints (SIJ) and spine were obtained at baseline, 1, 2 and 5 years. Each image was scored by 2 or 3 readers in 3 separate 'reading-waves'. The ra...
Inflammation of the sacroiliac joints and spine on MRI predicts structural chan...
Sepriano, Alexandre; Ramiro, Sofia; Landewé, Robert; Moltó, Anna; Claudepierre, Pascal; Wendling, Daniel; Dougados, Maxime; van der Heijde, DésiréeThis article is protected by copyright. All rights reserved.; OBJECTIVE: To test the impact of inflammation on MRI-structural changes occurring in the sacroiliac joints (SIJ) and the spine. METHODS: Patients with early axSpA from the DESIR cohort were included. MRIs of the SIJ (MRI-SIJ) and spine (MRI-spine), obtained at baseline, 2 and 5 years, were scored by 3 central readers. Inflammation and structural dama...
Identification of clinical phenotypes of peripheral involvement in patients wit...
López-Medina, Clementina; Chevret, Sylvie; Molto, Anna; Sieper, Joachim; Duruöz, Tuncay; Kiltz, Uta; Elzorkany, Bassel; Hajjaj-Hassouni, NajiaObjective To identify clusters of peripheral involvement according to the specific location of peripheral manifestations (ie, arthritis, enthesitis and dactylitis) in patients with spondyloarthritis (SpA) including psoriatic arthritis (PsA), and to evaluate whether these clusters correspond with the clinical diagnosis of a rheumatologist. Methods Cross-sectional study with 24 participating countries. Consecutiv...
Prevalence and distribution of peripheral musculoskeletal manifestations in spo...
López-Medina, Clementina; Molto, Anna; Sieper, Joachim; Duruöz, Tuncay; Kiltz, Uta; Elzorkany, Bassel; Hajjaj-Hassouni, Najia; Burgos-Vargas, RubenObjectives: To characterise peripheral musculoskeletal involvement in patients with spondyloarthritis (SpA) including psoriatic arthritis (PsA), across the world. Methods: Cross-sectional study with 24 participating countries. Patients with a diagnosis of axial SpA (axSpA), peripheral SpA (pSpA) or PsA according to their rheumatologist were included. The investigators were asked which diagnosis out of a list of...
5-year follow-up of spinal and sacroiliac MRI abnormalities in early axial spon...
Madari, Queeny; Sepriano, Alexandre; Ramiro, Sofia; Molto, Anna; Claudepierre, Pascal; Wendling, Daniel; Dougados, Maxime; Van Der Heijde, DesiréeFunding: g Devenir des Spondyloarthropathies Indifférenciées Récentes (DESIR) is financially supported by an unrestricted grant from Pfizer. AS is supported by a doctoral grant from 'Fundação para a Ciência e Tecnologia' (SFRH/ BD/108246/2015). The DESIR study is conducted as a Programme Hospitalier de Recherche Clinique with Assistance Publique Hopitaux de Paris as the sponsor. The DESIR study is also under th...
Spinal Radiographic Progression in Early Axial Spondyloarthritis
Ramiro, Sofia; van der Heijde, Désirée; Sepriano, Alexandre; van Lunteren, Miranda; Moltó, Anna; Feydy, Antoine; d'Agostino, Maria AntoniettaObjective: To analyze the progression of spinal radiographic damage in patients with early axial spondyloarthritis (SpA). Methods: Axial SpA patients from the DESIR (Devenir des Spondylarthropathies Indifférenciées Récentes) cohort with 5-year spinal (cervical and lumbar) radiographs available (n = 549) were included. Two- and 5-year modified Stoke Ankylosing Spondylitis Spine Score (mSASSS) progression and dev...
Percentage of progressors in imaging
Sepriano, Alexandre; Ramiro, Sofia; Landewé, Robert; Dougados, Maxime; Van Der Heijde, DesiréeStopping or preventing structural progression is a goal common to all inflammatory rheumatic diseases. Imaging may capture structural progression across diseases, but is susceptible to measurement error. Progression can be analysed as a continuous change score over time (eg, mean change of the van der Heijde-modified Sharp score) or as a binary change score (eg, percentage of progressors according to the modifi...
Sacroiliac radiographic progression in recent onset axial spondyloarthritis
Dougados, Maxime; Sepriano, Alexandre; Molto, Anna; Van Lunteren, Miranda; Ramiro, Sofia; De Hooge, Manouk; Van Den Berg, RosalineFunding Information: Acknowledgements the dESIr cohort was sponsored by the département de la recherche Clinique et du développement de l’Assistance publique–Hôpitaux de paris. this study is conducted under the umbrella of the French Society of rheumatology and InSErM (Institut national de la Santé et de la recherche Médicale). the database management is performed within the department of epidemiology and biost...