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Dysregulation of T cell receptor N-glycosylation: A molecular mechanism involve...

Dias, A; Dourado, J; Lago, P; Cabral, J; Marcos-Pinto, R; Salgueiro, P; Almeida, CR; Carvalho, S; Fonseca, S; Lima, M; Vilanova, M; Dinis-Ribeiro, M

The incidence of inflammatory bowel disease is increasing worldwide and the underlying molecular mechanisms are far from being fully elucidated. Herein, we evaluated the role of N-glycosylation dysregulation in T cells as a key mechanism in the ulcerative colitis (UC) pathogenesis. The evaluation of the branched N-glycosylation levelsandprofile of intestinalTcell receptor (TCR)wereassessedin colonic biopsies fr...

Date: 2014   |   Origin: Repositório Aberto da Universidade do Porto
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