13 documents found, page 1 of 2
Screening a Targeted Panel of Genes by Next-Generation Sequencing Improves Risk...
Matos, S; Bernardo, P; Esteves, S; Botelho de Sousa, A; Lemos, M; Ribeiro, P; Silva, M; Nunes, A; Lobato, J; Frade, MJ; Gomes da Silva, M; Chacim, SAlthough mutation profiling of defined genes is recommended for classification of acute myeloid leukemia (AML) patients, screening of targeted gene panels using next-generation sequencing (NGS) is not always routinely used as standard of care. The objective of this study was to prospectively assess whether extended molecular monitoring using NGS adds clinical value for risk assessment in real-world AML patients...
Innovative Equipment to Monitor and Control Salt Usage When Cooking: Acceptance...
Gonçalves, C.; Santos, T.; Padrão, Patrícia; Moreira, Pedro; Esteves, S; Oliveira, L; Pinho, OlíviaA large number of studies support the concept that high salt intake is the main risk factor in increasing blood pressure and cardiovascular diseases in the population. The main objective of this study is to analyze consumers preliminary satisfaction questionnaires regarding the use of an innovative prototype equipment to monitor and control salt during cooking the Salt Control H (SCH) during their participation...
A Potential Link Between Prolonged Cork Exposure and Intestinal-Type Sinonasal ...
Alpuim Costa, D; Monteiro, A; André, T; Esteves, S; Sargento, I; Ferreira, M; Alexandre, T; Clara, A; Freire, J; Moreira, AIntroduction: intestinal-type sinonasal adenocarcinoma (ITAC) is a rare epithelium tumor of the nasal cavities and paranasal sinuses. Exposure to wood and leather dusts is a strong etiological factor related to its development. Prolonged cork exposure has rarely been associated. Materials and methods: thirty-seven-year (1981-2018) retrospective cohort analysis of all consecutive patients with sinonasal cancer (...
Innovative equipment to monitor and control salt usage when cooking at home: iM...
Gonçalves, C; Silva-Santos, T; Abreu, S; Padrão, P; Graça, P; Oliveira, L; Esteves, S; Norton, P; Moreira, P; Pinho, OIntroduction. Excessive salt intake is a public health concern due to its deleterious impact on health. Most of the salt consumed come from those that are added when cooking. This study will improve knowledge on the effectiveness of interventions to reduce salt consumption among consumers. Methods and analysis. In this randomised clinical trial, we will be evaluating the efficacy of an intervention—the Salt Con...
Innovative equipment to monitor and control salt usage when cooking at home: IM...
Gonçalves, C.; Silva Santos, T; Abreu, S; Padrão, Patrícia; Graça, Pedro; Oliveira, L; Esteves, S; Norton, P; Moreira, Pedro; Pinho, OlíviaIntroduction Excessive salt intake is a public health concern due to its deleterious impact on health. Most of the salt consumed come from those that are added when cooking. This study will improve knowledge on the effectiveness of interventions to reduce salt consumption among consumers. Methods and analysis In this randomised clinical trial, we will be evaluating the efficacy of an intervention - the Salt Con...
High-throughput sequencing identifies 3 novel susceptibility genes for heredita...
Campos, C; Fragoso, S; Luís, R; Pinto, F; Brito, C; Esteves, S; Pataco, M; Santos, S; Machado, P; Vicente, JB; Rosa, JC; Cavaco, BM; Moura, C; Pojo, MCutaneous melanoma is one of the most aggressive human cancers due to its high invasiveness. Germline mutations in high-risk melanoma susceptibility genes have been associated with development hereditary melanoma; however, most genetic culprits remain elusive. To unravel novel susceptibility genes for hereditary melanoma, we performed whole exome sequencing (WES) on eight patients with multiple primary melanoma...
Lenalidomide is effective and safe for the treatment of patients with relapsed ...
João, C; Freitas, J; Gomes, F; Geraldes, C; Coelho, I; Neves, M; Lúcio, P; Esteves, S; Esteves, GPatients with multiple myeloma (MM) and severe renal impairment (SRI) have shorter survival than MM patients without renal failure. Although lenalidomide is a highly active drug, this immunomodulatory agent is frequently neglected in this context due to its predominant renal clearance and, consequently, an increased risk of toxicity. This risk might be overcome with the proper lenalidomide dose adjustment to re...
A Pilot Cost-Effectiveness Analysis of Treatments in Newly Diagnosed High-Grade...
Esteves, S; Alves, M; Castel-Branco, M; Stummer, WBACKGROUND: High-grade gliomas are aggressive, incurable tumors characterized by extensive diffuse invasion of the normal brain parenchyma. Novel therapies at best prolong survival; their costs are formidable and benefit is marginal. Economic restrictions thus require knowledge of the cost-effectiveness of treatments. Here, we show the cost-effectiveness of enhanced resections in malignant glioma surgery using ...
Robust Control of Maintenance-Phase Anesthesia
Lemos, JM; Caiado, DV; Costa, BA; Paz, LA; Mendonca, T; Rabico, R; Esteves, S; Seabra, MIn biomedical systems, feedback control can be applied whenever adequate sensors, actuators, and sufficiently accurate mathematical models are available. The key issue is the capacity of the control algorithm to tackle the large levels of uncertainty, both structured and unstructured, associated with patient dynamics. In the particular case of intravenous anesthesia considered here, manipulated variables are dr...
Incidence of postoperative residual neuromuscular blockade in the postanaesthes...
Esteves, S; Martins, M; Barros, F; Barros, F; Canas, M; Vitor, P; Seabra, M; Castro, M; Bastardo, ICONTEXT: Residual neuromuscular blockade still presents despite the use of intermediate duration muscle relaxants and is a risk factor for postoperative morbidity. OBJECTIVE: To determine the incidence of incomplete postoperative neuromuscular recovery from anaesthesia in a postanaesthesia care unit. DESIGN: Multicentre observational study. SETTING: Public Portuguese hospitals. PATIENTS: Adult patients schedule...