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Precision non-implantable neuromodulation therapies: a perspective for the depr...

Borrione, Lucas; Bellini, Helena; Razza, Lais Boralli; Ávila, Ana G.; Baeken, Chris; Brem, Anna-Katharine; Busatto, Geraldo; Carvalho, Andre F.

Current first-line treatments for major depressive disorder (MDD) include pharmacotherapy and cognitive-behavioral therapy. However, one-third of depressed patients do not achieve remission after multiple medication trials, and psychotherapy can be costly and time-consuming. Although non-implantable neuromodulation (NIN) techniques such as transcranial magnetic stimulation, transcranial direct current stimulati...


Bilateral DMPFC-rTMS Leads to Sustained Remission in Geriatric Treatment-Resist...

Sender, David; Nazar, Bruno Palazzo; Baczynski, Tathiana; Paes, Flávia; Fettes, Peter; Downar, Jonathan; Campos, Carlos; Nardi, Antonio Egidio

Major Depressive Disorder (MDD) is a highly prevalent condition that has been labeled the current leading cause of disability adjusted life years (Ferrari et al. 2013). Approximately 30% of MDD patients are treatment resistant, not achieving remission after two or more antidepressant trials (Baldessarini et al. 2015). In the geriatric population, MDD is associated with both lower rates of remission and increase...


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