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Invasive Bacterial Infections in Children With Sickle Cell Disease: 2014–2019

Gaschignard, J; Koehl, B; Rees, DC; Rincón-López, E; Vanderfaeillie, A; Pascault, A; Allali, S; Cela, E; Odièvre, MH; Hau, I; Oliveira, M; Guillaumat, C

Background: Children with sickle cell disease (SCD) are at a high risk of invasive bacterial infections (IBI). Universal penicillin prophylaxis and vaccination, especially against Streptococcus pneumoniae, have deeply changed its epidemiology. Analysis of IBI in children with SCD in a post-13-valent pneumococcal vaccine era is limited. Methods: Twenty-eight pediatric hospitals from 5 European countries retrospe...


Presentations of Children to Emergency Departments Across Europe and the COVID-...

Nijman, RG; Honeyford, K; Farrugia, R; Rose, K; Bognar, Z; Buonsenso, D; Da Dalt, L; De, T; Maconochie, IK; Parri, N; Roland, D; Alfven, T; Aupiais, C

Background: During the initial phase of the Coronavirus Disease 2019 (COVID-19) pandemic, reduced numbers of acutely ill or injured children presented to emergency departments (EDs). Concerns were raised about the potential for delayed and more severe presentations and an increase in diagnoses such as diabetic ketoacidosis and mental health issues. This multinational observational study aimed to study the numbe...


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