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Isolation and characterization of the acadevirus members BigMira and MidiMira i...
da Silva, Jéssica Duarte; Bens, Lene; Santos, Adriele J. do Carmo; Lavigne, Rob; Soares, José; Melo, Luís Daniel Rodrigues; Vallino, MartaProteus mirabilis is an opportunistic pathogen and is responsible for more than 40% of all cases of catheter-associated urinary tract infections (CAUTIs). Healthcare-associated infections have been aggravated by the constant emergence of antibiotic-resistant bacterial strains. Because of this, the use of phages to combat bacterial infections gained renewed interest. In this study, we describe the biological and...
Exploiting phage-derived carbohydrate depolymerases for combating infectious di...
Oliveira, Hugo Alexandre Mendes; Drulis-Kawa, Zuzanna; Azeredo, JoanaBacteria are protected against the immune system of their human hosts, as well as against predators such as phages, by expressing diverse surface carbohydrates. Some phages produce specialized depolymerases which can degrade those carbohydrates. Here, we discuss the biological role of depolymerases and how they can be exploited to develop new therapeutic strategies against pathogens.
Targeting biofilms using phages and their enzymes
Azeredo, Joana; García, Pilar; Drulis-Kawa, ZuzannaThe complex biofilm architecture composed of extracellular polymeric structures (EPS) provides a protective shield to physiologically diverse bacterial cells immersed in its structure. The evolutionary interplay between bacteria and their viruses (phages) forced the latter ones to develop specific strategies to overcome the biofilm defensive barriers and kill sessile cells. Phages are equipped with a wide panel...