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Cytotoxic and toxicological effects of phthalimide derivatives on tumor and nor...

Ferreira, Paulo Michel Pinheiro; Costa, Patrícia Marçal da; Costa, Arinice de Menezes; Lima, Daisy Jereissati Barbosa; Drumond, Renata Rosado

Eleven phthalimide derivatives were evaluated with regards to their antiproliferative activity on tumor and normal cells and possible toxic effects. Cytotoxic analyses were performed against murine tumors (Sarcoma 180 and B-16/F-10 cells) and peripheral blood mononuclear cells (PBMC) using MTT and Alamar Blue assays. Following, the investigation of cytotoxicity was executed by flow cytometry analysis and antitu...

Date: 2016   |   Origin: Oasisbr
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