6 documents found, page 1 of 1
The peptide secreted at the water to land transition in a model amphibian has a...
Barbosa, Eder Alves; Plácido, Alexandra; Moreira, Daniel C.; Albuquerque, Lucas; Dematei, Anderson; Silva-Carvalho, Amandda É.; Cabral, Wanessa F.Made available in DSpace on 2022-04-29T08:36:48Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-01-01; In addition to the morphophysiological changes experienced by amphibians during metamorphosis, they must also deal with a different set of environmental constraints when they shift from the water to the land. We found that Pithecopus azureus secretes a single peptide ([M + H]+ = 658.38 Da) at the develo...
The peptide secreted at the water to land transition in a model amphibian has a...
Barbosa, Eder Alves; Plácido, Alexandra; Moreira, Daniel C.; Albuquerque, Lucas; Dematei, Anderson; Carvalho, Amandda É. Silva; Cabral, Wanessa F.In addition to the morphophysiological changes experienced by amphibians during metamorphosis, they must also deal with a different set of environmental constraints when they shift from the water to the land. We found that Pithecopus azureus secretes a single peptide ([M + H]+ = 658.38 Da) at the developmental stage that precedes the onset of terrestrial behaviour. De novo peptide and cDNA sequencing revealed t...
Neuroprotective effects on microglia and insights into the structure–activity r...
Plácido, Alexandra; Amaral, Constança do Pais do; Teixeira, Cátia; Nogueira, Ariane; Brango-Vanegas, José; Barbosa, Eder Alves; Moreira, Daniel C.Tryptophyllins constitute a heterogeneous group of peptides that are one of the first classes of peptides identified from amphibian’s skin secretions. Here, we report the structural characterization and antioxidant properties of a novel tryptophyllin-like peptide, named PpT-2, isolated from the Iberian green frog Pelophylax perezi. The skin secretion of P. perezi was obtained by electrical stimulation and fract...
Mechanistic insights into the leishmanicidal and bactericidal activities of Bat...
Dematei, Anderson; Nunes, João B.; Moreira, Daniel C.; Jesus, Jéssica A.; Laurenti, Márcia D.; Mengarda, Ana C. A.; Vieira, Maria SilvaSnake venoms are important sources of bioactive molecules, including those with antiparasitic activity. Cathelicidins form a class of such molecules, which are produced by a variety of organisms. Batroxicidin (BatxC) is a cathelicidin found in the venom of the common lancehead (Bothrops atrox). In the present work, BatxC and two synthetic analogues, BatxC(C-2.15Phe) and BatxC(C-2.14Phe)des-Phe1, were assessed f...
The antioxidant peptide salamandrin-i: First bioactive peptide identified from ...
Plácido, Alexandra; Bueno, João; Barbosa, Eder A.; Moreira, Daniel C.; Dias, Jhones Do Nascimento; Cabral, Wanessa Felix; Albuquerque, PatríciaMade available in DSpace on 2020-12-12T02:01:06Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-04-01; Universidade Estadual Paulista; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Fundação para a Ciência e a Tecnologia; Amphibian skin is a multifunctional organ that plays key roles in defense, breathing, and wat...
Structure and function of a novel antioxidant peptide from the skin of tropical...
Barbosa, Eder Alves; Oliveira, Ana; Plácido, Alexandra; Socodato, Renato; Portugal, Camila C.; Mafud, Ana Carolina; Ombredane, Alicia S.The amphibian skin plays an important role protecting the organism from external harmful factors such as microorganisms or UV radiation. Based on biorational strategies, many studies have investigated the cutaneous secretion of anurans as a source of bioactive molecules. By a peptidomic approach, a novel antioxidant peptide (AOP) with in vitro free radical scavenging ability was isolated from Physalaemus natter...