5 documents found, page 1 of 1
Interleukin-4 and Atopic Dermatitis
T, Torres; Mendes-Bastos, Pedro; Cruz, Maria J.; Duarte, Bruno; Filipe, Paulo; Lopes, Maria J.P.; Gonçalo, MargaridaPublisher Copyright: © The Author(s) 2025.; Atopic dermatitis (AD) is a common chronic inflammatory skin condition that significantly impairs patients’ quality of life as a result of intense itching and persistent eczematous lesions. Although AD has a multifaceted etiology—including genetic predisposition, environmental triggers, barrier dysfunction, and dysregulated immune responses—interleukin-4 (IL-4) has a ...
Real-World Effectiveness and Safety of Dupilumab, Tralokinumab, and Upadacitini...
Torres, Tiago; Yeung, Jensen; Prajapati, Vimal H.; Ribero, Simone; Balato, Anna; Marzano, Angelo Valerio; Cruz, Maria João; Paiva-Lopes, MariaIntroduction: Evaluating the real-world effectiveness, safety, and tolerability of targeted biologic and non-biologic therapies in patients with atopic dermatitis (AD) treated in routine clinical practice remains crucial. In this international, multicenter, retrospective, comparative study we aimed to evaluate the 52-week effectiveness, safety, and tolerability of dupilumab, tralokinumab, and upadacitinib in pa...
Improving the integrity and the microstructural features of electron beam welds...
Rabl, Antonia; Pixner, Florian; Duarte, Bruno; Blatesic, Danijel; Béal, Coline; Enzinger, NorbertMartensitic 9–12% chromium steels present the most preferred material group for high-temperature components in thermal power plants. Previous investigations revealed that due to the use of a creep-resistant martensitic steel strengthened with boron and nitrogen (MarBN), the minimum creep rate can significantly be decreased. Furthermore, the formation of the fine-grained heat-affected zone (FGHAZ) due to welding...
Rhythm and Structure
Duarte, BrunoUID/FIL/00183/2013; Brecht’s adaptation of Sophocles’ Antigone in 1948 was openly a political gesture that aspired to the complete rationalization of Greek Tragedy. From the beginning, Brecht made it his task to wrench ancient tragic poetry out of its “ideological haze”, and proceeded to dismantle and eliminate what he named the “element of fate”, the crucial substance of tragic myth itself. However, his encoun...
Requoting the Arcades
Duarte, BrunoUID/FIL/00183/2013; By contrasting Walter Benjamin’s fragmentary theory of quotation to the different ways his work has itself undergone quotation thus far, a new insight can be gained into the perception of the materiality and visuality of texts. The so-called Passagen-Werk, the project on the Parisian Arcades which Benjamin pursued for more than ten years until the end of his life, is the overflowing, yet voi...