7 documents found, page 1 of 1
Low prevalence of copy number variation in pfmdr1 and pfpm2 in Plasmodium falci...
Duarte, Denise; Manuel, Francisco; Dias, Ana; Sacato, Esmeralda; Taleingue, Elsa; Daniel, Elsa; Simão, Francisco; Varandas, Luís; Antunes, Maria LinaPublisher Copyright: © 2025. The Author(s). This research was partially supported by Fundação para a Ciência e a Tecnologia GHTM UID/04413/2020 and LA-REAL—LA/P/0117/2020; Denise Duarte is the recipient of the FCT grant 2022.12736. BD.; BACKGROUND: Malaria is the parasitic disease with the highest global morbidity and mortality. According to estimates from the World Health Organization (WHO), there were around ...
Unlocking the potential of snake venom-based molecules against the malaria, Cha...
Almeida, José Rafael; Gomes, Ana S. M.; Mendes, Bruno; Aguiar, Luísa; Ferreira, Mariana; Brioschi, Mariana Borges Costa; Duarte, DeniseFunding Information: This work received financial support from PT national funds ( FCT/MCTES , Fundação para a Ciência e Tecnologia and Ministério da Ciência, Tecnologia e Ensino Superior) through the project CIRCNA/BRB/0281/2019 . Funding Information: This work received financial support from PT national funds (FCT/MCTES, Fundação para a Ciência e Tecnologia and Ministério da Ciência, Tecnologia e Ensino Super...
Anti-malarial resistance in Mozambique
da Silva, Clemente; Matias, Daniela; Dias, Brigite; Cancio, Beatriz; Silva, Miguel; Viegas, Rúben; Chivale, Nordino; Luis, Sonia; Salvador, Crizolgo© 2023. The Author(s).; BACKGROUND: Malaria remains one of the most serious public health problems in sub-Saharan Africa and Mozambique is the world's fourth largest contributor, with 4.7% of disease cases and 3.6% of total deaths due to malaria. Its control relies on the fight against the vector and treatment of confirmed cases with anti-malarial drugs. Molecular surveillance is an important tool for monitorin...
Facile Access to Structurally Diverse Antimalarial Indoles Using a One-Pot A3 C...
da Silva, Gustavo; Luz, André F.S.; Duarte, Denise; Fontinha, Diana; Silva, Vera L.M.; Almeida Paz, Filipe A.; Madureira, Ana M.; Simões, SandraFunding Information: . The authors acknowledge the financial support provided by Fundação para a Ciência e a Tecnologia (FCT Portugal) through the PhD grant research project SFRH/BD/103412/2014 and projects PTDC/MED‐QUI/30021/2017, PTDC/MED‐CAR/31322/2017 and PTDC/SAU‐TOX/32515/2017, and the research unit GHTM (UID/Multi/04413/2013 and GHTM‐UID/04413/2020). We thank MR4 for providing us with malaria parasites c...
Drug-Derived Surface-Active Ionic Liquids
Silva, Ana Teresa; Oliveira, Isabel S.; Gomes, Joana; Aguiar, Luísa; Fontinha, Diana; Duarte, Denise; Nogueira, Fátima; Prudêncio, MiguelFunding Information: The authors thank Fundação para a Ciência e Tecnologia (FCT, Portugal), for funding Research Units LAQV‐REQUIMTE (UIDB/50006/2020), CIQUP (UIDB/00081/2020), and GHTM (UID/Multi/04413/2013), and for project grant PTDC/BTM‐SAL/29786/2017. ATS thanks FCT and Sociedade Portuguesa de Química (SPQ, Portugal) for her doctoral grant SFRH/BD/150649/2020 Publisher Copyright: © 2021 Wiley-VCH GmbH; In...
Indole-Containing Pyrazino[2,1-b]quinazoline-3,6-diones Active against Plasmodi...
Long, Solida; Duarte, Denise; Carvalho, Carla; Oliveira, Rafael; Santarém, Nuno; Palmeira, Andreia; Resende, Diana I. S. P.; Silva, Artur M. S.Funding Information: This research was supported by national funds through FCT-Foundation for Science and Technology within the scope of UIDB/04423/2020, UIDP/04423/2020, IUD/04413/2020 and under the project PTDC/SAU-PUB/287336/2017 (reference POCI-01-0145-FEDER-028736), cofinanced by COMPETE 2020, Portugal 2020 and the European Union through the ERDF and by FCT through national funds, as well as CHIRALBIOACTIV...
A hypometabolic defense strategy against malaria
Ramos, Susana; Ademolue, Temitope W; Jentho, Elisa; Wu, Qian; Guerra, Joel; Martins, Rui; Pires, Gil; Weis, Sebastian; Carlos, Ana Rita; Mahú, InêsFunding Information: We thank Dr. Silvia Portugal (Max Plank Institute, Berlin) and Dr. Jessica Thompson (Instituto Gulbenkian de Ciência; IGC) for their critical review of the manuscript; Dr. Joanne Thompson (University of Edinburgh) for PcAS-GFPML parasites; BEI Resources for P. falciparum parasites (MRA-1029, deposited by Andrew M. Talman and Robert E. Sinden); and excellent support from IGC's Advanced Imagi...