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Individualized Fortification Based on Measured Macronutrient Content of Human M...

Cardoso, M; Virella, D; Papoila, AL; Alves, M; Macedo, I; e Silva, D; Pereira-da-Silva, L

The optimal method for human milk (HM) fortification has not yet been determined. This study assessed whether fortification relying on measured HM macronutrient content (Miris AB analyzer, Upsala, Sweden) composition is superior to fortification based on assumed HM macronutrient content, to optimize the nutrition support, growth, and body composition in infants born at <33 weeks' gestation. In a mixed-cohort st...


Influence of Human Milk on Very Preterms' Gut Microbiota and Alkaline Phosphata...

Morais, J; Marques, C; Faria, A; Teixeira, D; Barreiros-Mota, I; Durão, C; Araújo, J; Ismael, S; Brito, S; Cardoso, M; Macedo, I; Pereira, E; Tomé, T

The FEEDMI Study (NCT03663556) evaluated the influence of infant feeding (mother’s own milk (MOM), donor human milk (DHM) and formula) on the fecal microbiota composition and alkaline phosphatase (ALP) activity in extremely and very preterm infants (≤32 gestational weeks). In this observational study, preterm infants were recruited within the first 24 h after birth. Meconium and fecal samples were collected at ...


Customized Human Milk Fortification Based on Measured Human Milk Composition to...

Cardoso, M; Virella, D; Macedo, I; Silva, Diana; Pereira da Silva, L

Adequate nutrition of very preterm infants comprises fortification of human milk (HM), which helps to improve their nutrition and health. Standard HM fortification involves a fixed dose of a multi-nutrient HM fortifier, regardless of the composition of HM. This fortification method requires regular measurements of HM composition and has been suggested to be a more accurate fortification method. This observation...


Customized Human Milk Fortification Based on Measured Human Milk Composition to...

Cardoso, M; Virella, D; Macedo, I; Silva, D; Pereira-da-Silva, L

Adequate nutrition of very preterm infants comprises fortification of human milk (HM), which helps to improve their nutrition and health. Standard HM fortification involves a fixed dose of a multi-nutrient HM fortifier, regardless of the composition of HM. This fortification method requires regular measurements of HM composition and has been suggested to be a more accurate fortification method. This observation...


Influence of Human Milk on Very Preterms' Gut Microbiota and Alkaline Phosphata...

Morais, J; Marques, C; Faria, A; Teixeira, D; Barreiros-Mota, I; Durão, C; Araújo, J; Ismael, S; Brito, S; Cardoso, M; Macedo, I; Pereira, E; Tomé, T

The FEEDMI Study (NCT03663556) evaluated the influence of infant feeding (mother's own milk (MOM), donor human milk (DHM) and formula) on the fecal microbiota composition and alkaline phosphatase (ALP) activity in extremely and very preterm infants (≤32 gestational weeks). In this observational study, preterm infants were recruited within the first 24 h after birth. Meconium and fecal samples were collected at ...


Extremely preterm neonates have more Lactobacillus in meconium than very preter...

Morais, J; Marques, C; Teixeira, D; Durão, C; Faria, A; Brito, S; Cardoso, M; Macedo, I; Pereira, E; Tomé, T; Calhau, C

Growing evidence suggests that maternal microbiota can influence the neonates’ gut colonization. However, the mechanisms of vertical bacterial transmission remain poorly defined. We believed that the first colonizers of the newborn come from the mother’s gut and vagina during pregnancy and that this is independent of the mode of delivery. We conducted an observational longitudinal study to evaluate the link bet...


FEEDMI: A Study Protocol to Determine the Influence of Infant-Feeding on Very-P...

Morais, J; Marques, C; Teixeira, D; Durão, C; Faria, A; Brito, S; Cardoso, M; Macedo, I; Tomé, T; Calhau, C

Background: Preterm infants are especially vulnerable to gut microbiota disruption and dysbiosis since their early gut microbiota is less abundant and diverse. Several factors may influence infants’ gut microbiota, such as the mother’s diet, mode of delivery, antibiotic exposure, and type of feeding. Objectives: This study aims to examine the factors associated with very-preterm neonate’s intestinal microbiota,...


FEEDMI: A Study Protocol to Determine the Influence of Infant-Feeding on Very-P...

Morais, J; Marques, C; Teixeira, D; Durão, C; Faria, A; Brito, S; Cardoso, M; Macedo, I; Tomé, T; Calhau, C

Background: Preterm infants are especially vulnerable to gut microbiota disruption and dysbiosis since their early gut microbiota is less abundant and diverse. Several factors may influence infants' gut microbiota, such as the mother's diet, mode of delivery, antibiotic exposure, and type of feeding. Objectives: This study aims to examine the factors associated with very-preterm neonate's intestinal microbiota,...


Male Sex is an Independent Risk Factor for Poor Neurodevelopmental Outcome at 2...

Macedo, I; Pereira-da-Silva, L; Brito, L; Cardoso, M

To determine associations between sex and neurodevelopmental outcomes in human milk-fed very preterm infants, adjusted to early measured nutrient intakes and other neonatal cofactors.


The Fortification Method Relying on Assumed Human Milk Composition Overestimate...

Macedo, I; Pereira-da-Silva, L; Cardoso, M

BACKGROUND: To achieve recommended nutrient intakes in preterm infants, the target fortification method of human milk (HM) was proposed as an alternative to standard fortification method. We aimed to compare assumed energy and macronutrient intakes based on standard fortified HM with actual intakes relying on measured composition of human milk (HM), in a cohort of HM-fed very preterm infants. METHODS: This stud...


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