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2023 Update

Bertoluci, Marcello Casaccia; Silva Júnior, Wellington S; Valente, Fernando; Araujo, Levimar Rocha; Lyra, Ruy; de Castro, João Jácome

© 2023. The Author(s).; BACKGROUND: The management of antidiabetic therapy in people with type 2 diabetes (T2D) has evolved beyond glycemic control. In this context, Brazil and Portugal defined a joint panel of four leading diabetes societies to update the guideline published in 2020. METHODS: The panelists searched MEDLINE (via PubMed) for the best evidence from clinical studies on treating T2D and its cardior...


Liraglutide Effectiveness in Type 2 Diabetes

Silva-Nunes, José; Nascimento, Edite; Louro, Joana; Dores, Jorge; Laginha, Teresa; Gonçalves-Ferreira, Ana; Alves, Marta; Souto, Selma B.; Cunha, Nelson

Funding Information: This study was promoted by the Portuguese Society of Diabetology (SPD) with the sponsorship of Novo Nordisk Portugal, Lda. Statistical analysis and medical writing were conducted by W4Research with the funding of Novo Nordisk Portugal, Lda. The study was conducted by the SPD, with no influence from the sponsor. Publisher Copyright: © 2022 by the authors.; Liraglutide is a long-acting glucag...


Prediabetes blunts DPP4 genetic control of postprandial glycaemia and insulin s...

Patarrão, Rita S.; Duarte, Nádia; Coelho, Inês; Ward, Joey; Ribeiro, Rogério T.; Meneses, Maria João; Andrade, Rita; Costa, João; Correia, Isabel

Funding Information: The PREVADIAB-2 study was supported by a grant from the Portuguese Directorate General of Health. This work was financed by Fundação para a Ciência e Tecnologia (reference number PTDC/BIM/MET/4265/2014), by iNOVA4Health UIDB/Multi/04462/2020 and by ONEIDA (project E-411021.01, Lisboa-01-0145-FEDER-016417, co-funded by FEEI [Fundos Europeus Estruturais e de Investimento] from Programa Operac...


Metabolic Footprint, towards Understanding Type 2 Diabetes beyond Glycemia

Pina, Ana Lúcia F.; Patarrao, Rita S.; Ribeiro, Rogerio T.; Penha-Goncalves, Carlos; Raposo, Joao F.; Gardete-Correia, Luis; Duarte, Rui

Type 2 diabetes (T2D) heterogeneity is a major determinant of complications risk and treatment response. Using cluster analysis, we aimed to stratify glycemia within metabolic multidimensionality and extract pathophysiological insights out of metabolic profiling. We performed a cluster analysis to stratify 974 subjects (PREVADIAB2 cohort) with normoglycemia, prediabetes, or non-treated diabetes. The algorithm w...


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