119 documents found, page 1 of 12
Antimicrobial and wound healing effects associated to cytocompatibility and the...
Machado, Alexandra M.; Marto, Joana; Gonçalves, Lídia Maria; Ribeiro, Helena Margarida; Duarte, Aida; Tomás, Andreia; Falcão, Soraia; Vilas-Boas, MiguelOwing to its applications in both food and pharmaceutical industries honey is regarded as a functional product. This study evaluated 32 Portuguese monofloral honeys and their activity was compared with manuka honey 850 + . The antimicrobial activity was determined against Gram-positive and negative bacteria, and yeast. Antioxidant activity, wound healing ability, and cell viability were studied in the human ker...
Identifying phage Lysins through genomic analysis of prophages from Acinetobact...
Raposo, Maria Leonor; Pimentel, Ana Carolina; Manageiro, Vera; Duarte, Aida; Caniça, Manuela; Vale, Filipa F.Acinetobacter baumannii is a Gram-negative opportunistic pathogen, responsible for nosocomial infections worldwide. In recent years, this microorganism has acquired resistance to various antibiotics, prompting the World Health Organization (WHO) to declare carbapenem-resistant A. baumannii (CRAB) a critical priority microorganism requiring urgent attention and the development of new therapeutic options. Here, w...
Antimicrobial and wound healing effects associated to cytocompatibility and the...
Machado, Alexandra M.; Marto, Joana; Gonçalves, Lídia Maria; Ribeiro, Helena Margarida; Duarte, Aida; Tomás, Andreia; Falcão, Soraia I.Owing to its applications in both food and pharmaceutical industries honey is regarded as a functional product. This study evaluated 32 Portuguese monofloral honeys and their activity was compared with manuka honey 850 +. The antimicrobial activity was determined against Gram-positive and negative bacteria, and yeast. Antioxidant activity, wound healing ability, and cell viability were studied in the human kera...
Antimicrobial activity of prophage endolysins against critical Enterobacteriace...
Gonçalves, Tiago; Marques, Andreia T.; Manageiro, Vera; Tanoeiro, Luís; Vital, Joana S.; Duarte, Aida; Vítor, Jorge M. B.; Caniça, ManuelaEnterobacteriaceae species are part of the 2017 World Health Organization antibiotic-resistant priority pathogens list for development of novel medicines. Multidrug-resistant Klebsiella pneumoniae is an increasing threat to public health and has become a relevant human pathogen involved in life-threatening infections. Phage therapy involves the use of phages or their lytic endolysins as bioagents for the treatm...
Antimicrobial activity of prophage endolysins against critical Enterobacteriace...
Gonçalves, Tiago; Marques, Andreia T.; Manageiro, Vera; Tanoeiro, Luis; Vital, Joana S.; Duarte, Aida; Vítor, Jorge M. B.; Caniça, ManuelaEnterobacteriaceae species are part of the 2017 World Health Organization antibiotic-resistant priority pathogens list for development of novel medicines. Multidrug-resistant Klebsiella pneumoniae is an increasing threat to public health and has become a relevant human pathogen involved in life-threatening infections. Phage therapy involves the use of phages or their lytic endolysins as bioagents for the treatm...
Antimicrobial activity of prophage endolysins against critical Enterobacteriace...
Gonçalves, Tiago; Marques, Andreia T.; Manageiro, Vera; Tanoeiro, Luis; Vital, Joana S.; Duarte, Aida; Vítor, Jorge M.B.; Caniça, ManuelaEnterobacteriaceae species are part of the 2017 World Health Organization antibiotic-resistant priority pathogens list for development of novel medicines. Multidrug-resistant Klebsiella pneumoniae is an increasing threat to public health and has become a relevant human pathogen involved in life-threatening infections. Phage therapy involves the use of phages or their lytic endolysins as bioagents for the treatm...
In vitro biological activity and phenolic profile of selected portuguese monofl...
Machado, Alexandra M.; Marto, Joana; Gonçalves, Lídia Maria; Ribeiro, Helena Margarida; Duarte, Aida; Tomás, Andreia; Falcão, Soraia; Vilas-Boas, MiguelPortuguese monofloral honeys from carob tree, chestnut, bell heather, eucalyptus, incense, orange, and strawberry tree, were evaluated in vitro for antimicrobial, antioxidant, wound healing, and cell viability effect, compared to manuka honey 850+. Antimicrobial activity was determined against Gram+-and Gram- bacteria and yeast. Antioxidants, wound healing, and cell viability effects were studied in the Human K...
Virulence factors in carbapenem-resistant hypervirulent Klebsiella pneumoniae
Mendes, Gabriel; Santos, Maria Leonor; Ramalho, João Francisco; Duarte, Aida; Caneiras, CatiaHypervirulence and carbapenem-resistant have emerged as two distinct evolutionary pathotypes of Klebsiella pneumoniae, with both reaching their epidemic success and posing a great threat to public health. However, as the boundaries separating these two pathotypes fade, we assist a worrisome convergence in certain high-risk clones, causing hospital outbreaks and challenging every therapeutic option available. To...
Virulence factors in carbapenem-resistant hypervirulent Klebsiella pneumoniae
Mendes, Gabriel; Santos, Maria Leonor; Ramalho, João F.; Duarte, Aida; Caneiras, CátiaHypervirulence and carbapenem-resistant have emerged as two distinct evolutionary pathotypes of Klebsiella pneumoniae, with both reaching their epidemic success and posing a great threat to public health. However, as the boundaries separating these two pathotypes fade, we assist a worrisome convergence in certain high-risk clones, causing hospital outbreaks and challenging every therapeutic option available. To...
Emergence of KPC-3- and OXA-181-producing ST13 and ST17 Klebsiella pneumoniae i...
Elias, Rita; Spadar, Anton; Hendrickx, Antoni P A; Bonnin, Remy A; Dortet, Laurent; Pinto, Margarida; Phelan, Jody E; Portugal, Isabel; Campino, SusanaBackground Carbapenem-resistant Klebsiella pneumoniae (CRKP) strains are of particular concern, especially strains with mobilizable carbapenemase genes such as blaKPC, blaNDM or blaOXA-48, given that carbapenems are usually the last line drugs in the β-lactam class and, resistance to this sub-class is associated with increased mortality and frequently co-occurs with resistance to other antimicrobial classes. Ob...