13 documents found, page 1 of 2

Antifibrotics in rheumatoid arthritis-associated interstitial lung disease – re...

Publisher Copyright: © 2024 Sociedade Portuguesa de Reumatologia.; Introduction: Interstitial lung disease (ILD) is the most common pulmonary manifestation of rheumatoid arthritis (RA) and is associated with an increased mortality. Clinical trials have shown that antifibrotics (nintedanib and pirfenidone) can slow the progression of connective tissue disease-associated ILD. This study aims to evaluate the effec...

Assessment of calcinosis in Portuguese patients with systemic sclerosis: a mult...

Introduction/objectives: The study aims to define the clinical and subclinical calcinosis prevalence, the sensitivity of radiographed site and clinical method for its diagnosis, and the phenotype of Portuguese systemic sclerosis (SSc) patients with calcinosis. Method: A cross-sectional multicenter study was conducted with SSc patients fulfilling Leroy/Medsger 2001 or ACR/EULAR 2013 classification criteria, regi...

Antibiotic resistance in the drinking water: old and new strategies to remove a...

Bacterial resistance is a naturally occurring process. However, bacterial antibiotic resistance has emerged as a major public health problem in recent years. The accumulation of antibiotics in the environment, including in wastewaters and drinking water, has contributed to the development of antibiotic resistant bacteria and the dissemination of antibiotic resistance genes (ARGs). Such can be justified by the g...

Health-related quality of life and disability in adults with juvenile idiopathi...

Objective: To compare physical disability, mental health, fatigue and health-related quality of life (HRQoL) across juvenile idiopathic arthritis (JIA) categories in adulthood and between JIA and adult-onset rheumatic diseases. Methods: Cross-sectional analysis nested in a cohort of adult patients with JIA registered in the Rheumatic Diseases Portuguese Register (Reuma.pt). Physical disability (Health Assessmen...

Gender differences in clinical features and outcomes of a Portuguese systemic s...

Evidence for the role of sex in the clinical manifestations of systemic sclerosis (SSc) patients is emerging. Some multicenter cohorts have shown that male SSc patients have more severe disease and worse survival. To assess the differences in clinical manifestations and survival in Portuguese SSc patients according to gender. Data from male and female adult SSc patients included in the Rheumatic Diseases Portug...

Rituximab in connective tissue disease–associated interstitial lung disease

Introduction/objectives: To evaluate rituximab (RTX) effectiveness and safety in patients with interstitial lung disease (ILD) related to connective tissue diseases (CTD). Methods: Retrospective multicenter cohort study, including patients with CTD-ILD, followed in six Portuguese rheumatology departments until November 2018. ILD diagnosis was based on high-resolution CT (HRCT) and/or lung biopsy. Results of HRC...

Anti-fibrotic nintedanib—a new opportunity for systemic sclerosis patients?

Systemic sclerosis is a connective tissue disease characterized by progressive skin thickening and a wide spectrum of internal organ involvement. Pathogenesis includes vasculopathy, inflammation, and fibrosis. Although immunosuppressants such as cyclophosphamide and mycophenolate mofetil have shown some benefit in interstitial lung disease management, it is still a major cause of morbi-mortality in these patien...

O jogo como recurso de motivação e aprendizagem das ciências no 1.º ciclo

A temática deste Relatório Final “O jogo como recurso de motivação e aprendizagem das ciências no 1º ciclo” relativo ao curso de Mestrado em Educação Pré-escolar e Ensino do 1º ciclo do ensino básico, surge de forma a colmatar as dificuldades e o desinteresse encontrados na turma em estudo, na área das ciências. O jogo didático, surge assim como estratégia motivacional para despertar o interesse e a vontade de ...

The choroid plexus as a sex hormone target: Functional implications

The choroid plexuses (CPs) are highly vascularized branched structures that protrude into the ventricles of the brain, and form a unique interface between the blood and the cerebrospinal fluid (CSF). In recent years, novel functions have been attributed to this tissue such as in immune and chemical surveillance of the central nervous system, brain development, adult neurogenesis and circadian rhythm regulation....

Cognitive Emotion Regulation Strategies and Depressive Symptoms: Gender's Moder...