2 documents found, page 1 of 1
Identification of genes and the signal transduction pathways involved in the re...
Duarte, Ana Marta GomesAfter many years of research, S. cerevisiae was accepted as a powerful model that allows increasing our comprehension about the underlying mechanisms of apoptosis in more complex and less accessible organisms. So, to better understand these apoptotic mechanisms we performed a functional analysis, at whole-genome scale, with the Euroscarf mutants collection. This analysis reveled 2159 resistant mutants and 391 m...
Genome-wide identification of genes involved in the positive and negative regul...
Sousa, Marlene; Duarte, Ana Marta Gomes; Fernandes, Tânia Alícia Ribeiro; Chaves, S. R.; Pacheco, Andreia; Leão, Cecília; Côrte-Real, ManuelaBackground: Acetic acid is mostly known as a toxic by-product of alcoholic fermentation carried out by Saccharomyces cerevisiae, which it frequently impairs. The more recent finding that acetic acid triggers apoptotic programmed cell death (PCD) in yeast sparked an interest to develop strategies to modulate this process, to improve several biotechnological applications, but also for biomedical research. Indeed,...