114 documents found, page 1 of 12
Sustainability assessment of collagen extraction from fish skins: A comparative...
Miguel P. Batista; Fernández, Naiara; Gaspar, Frédéric B.; Bronze, MR; Duarte, Ana Rita C.; Ortigueira, Joana; Lopes, TiagoABSTRACT: Collagen from blue shark skins offers a promising solution to utilize fishery by-products, reducing waste and improving resource efficiency. This study develops green chemistry-based extraction processes to minimize reliance on traditional chemical methods and lower environmental impacts, prioritizing sustainability and circularity. Two methods for collagen extraction are compared: a conventional alka...
Insights into therapeutic liquid mixtures and formulations towards tuberculosis...
Santos, Filipa; Pires, David; Anes, Elsa; Duarte, Ana Rita C.Therapeutic liquid mixtures, as deep eutectic systems, are considered a sustainable strategy that can be useful for the modification and enhancement of the pharmacokinetics and pharmacodynamics of different active ingredients. In this study, we assessed the stability and antibacterial activity of therapeutic liquid formulations prepared with anti-tuberculosis drugs. Tuberculosis therapy presents various pitfall...
Is the association between sleep and socio-emotional development mediated by we...
Duarte, Ana Rita C.; Martins, Silvana; Lopes, Luí; Silva, Maria José; Augusto, Cláudia; Santos, Rute; Rosário, RafaelaIntroduction: Childhood is an important stage for socio-emotional development. Understanding the associations of lifestyle habits with the healthy development of social and emotional skills is crucial for better interventions early in life. This study aims to analyze the association between sleep and socio-emotional development in toddlers aged 12 to 36 months and examine whether weight mediated these associat...
Promoting cardiovascular health using a recommendation system
Duarte, Ana Rita C.; Belo, OrlandoLifestyle habits have a direct influence on people’s health. Regular physical activity, combined with good nutrition, helps to prevent the early onset of diseases such as cardiovascular disease. In fact, a significant number of patients diagnosed with cardiovascular disease is associated with a poor diet and a sedentary routine. However, in today’s busy life, it is not always easy to find the motivation for ado...
A comparative study of data mining techniques applied to renal-cell carcinomas
Duarte, Ana Rita C.; Peixoto, Hugo; Machado, José ManuelDespite being one of the deadliest diseases and the enormous evolution in fighting it, the best methods to predict kidney cancer, namely Renal-Cell Carcinomas (RCC), are not well-known. One of the solutions to accelerate the current knowledge about RCC is through the use of Data Mining techniques based on patients' personal and clinical data. Therefore, it is crucial to understand which techniques are the most ...
Preventing cardiovascular disease development establishing cardiac well-being i...
Duarte, Ana Rita C.; Belo, OrlandoCardiovascular disease is responsible for an alarming number of deaths worldwide. Nowadays more people die of cardiovascular disease than any other type of disease. A considerable number of these deaths is caused by preventable risk factors. Thus, it is necessary to invest in cardiovascular disease prevention and take urgent action to reverse this scenario, reducing risky behaviours. The availability of a tool ...
Optimal design of THEDES based on Perillyl Alcohol and Ibuprofen
Silva, Eduardo Alexandre Pereira; Oliveira, F.; Silva, Joana M.; Matias, A.; Reis, R. L.; Duarte, Ana Rita C.Therapeutic deep eutectic systems (THEDES) have dramatically expanded their popularity in the pharmaceutical field due to their ability to increase active pharmaceutical ingredients (APIs) bioavailability. However, their biological performance has not yet been carefully scrutinized. Herein, THEDES based on the binary mixture of perillyl alcohol (POH) and ibuprofen (IBU) were prepared using different molar ratio...
Collagen from Atlantic cod (Gadus morhua) skins extracted using CO2 acidified w...
Sousa, Rita Alexandra Oliveira; Martins, Eva; Carvalho, Duarte Nuno; Alves, Ana Luísa Silva; Oliveira, Ana Catarina Freitas Salazar; Duarte, Ana Rita C.The extraction of collagen from fish skins is being proposed as strategy for valorization of marine origin by-products, being a sustainable alternative to mammal collagen. The method commonly uses solutions of organic acids, but new methodologies are arising, aiming to improve process yields and/or the properties of the resulting products. In this work, skins removed from salt brine Atlantic cod (Gadus morhua) ...
Therapeutic role of deep eutectic solvents based on menthol and saturated fatty...
Silva, Joana M.; Pereira, Carolina Jesus Vieira; Mano, Francisca; Silva, Eduardo; Castro, Vânia Isabel Baptista; Sá-Nogueira, Isabel; Reis, R. L.The breakthroughs achieved in green solvents promote the emergence of therapeutic deep eutectic solvents (THEDES), which possess intriguing possible applications in the biomedical field. Herein, the main aim was to unravel the biomedical potential of hydrophobic THEDES based in menthol and saturated fatty acids with different chain lengths (e.g., stearic acid (SA), myristic acid (MA), and lauric acid (LA)). Our...
Predicting postoperative complications for gastric cancer patients using data m...
Peixoto, Hugo; Francisco, Alexandra; Duarte, Ana Rita C.; Esteves, Márcia; Oliveira, Sérgio Manuel Costa; Lopes, Vítor; Abelha, AntónioGastric cancer refers to the development of malign cells that can grow in any part of the stomach. With the vast amount of data being collected daily in healthcare environments, it is possible to develop new algorithms which can support the decision-making processes in gastric cancer patients treatment. This paper aims to predict, using the CRISP-DM methodology, the outcome from the hospitalization of gastric c...