16 documents found, page 1 of 2

Remission versus low disease activity as treatment targets in rheumatoid arthri...

Objectives: To evaluate the impact of using Simplified Disease Activity Index (SDAI)-LDA (low disease activity) versus different definitions of remission as a treatment target in established rheumatoid arthritis. Methods: A meta-epidemiological study of individual patient data from eight randomised controlled trials was performed. Four definitions of the target were considered at 6 months: (1) SDAI-LDA: SDAI≤11...

Remission definitions guiding immunosuppressive therapy in rheumatoid arthritis...

Objective: To assess which definition of remission best predicts good radiographic outcome (GRO) and good functional outcome (GFO) in rheumatoid arthritis, focusing the updated American College of Rheumatology/European Alliance of Associations for Rheumatology criteria. Material and methods: Meta-analyses of individual patient data (IPD) from randomised controlled trials (RCTs). Six definitions of remission wer...

A Rare Cause of Common Pain: Herpes Zoster-Induced Sciatica

N/a.; N/a.

MITIG.RA: study protocol of a tailored psychological intervention for managing ...

Background Despite remarkable medical advances in the treatment of rheumatoid arthritis (RA), a subset of patients fails to achieve complete clinical remission, as the Patient Global Assessment (PGA) of disease activity remains above 1, even after the inflammatory process is brought under control. This so-called state of ‘PGA-near-remission’ negatively impacts individuals’ functioning and potentiates inadequate...

Human Bone Marrow Mesenchymal Stromal/Stem Cells Regulate the Proinflammatory R...

Rheumatoid arthritis (RA) is a disabling autoimmune disease whose treatment is ineffective for one-third of patients. Thus, the immunomodulatory potential of mesenchymal stromal/stem cells (MSCs) makes MSC-based therapy a promising approach to RA. This study aimed to explore the immunomodulatory action of human bone marrow (BM)-MSCs on myeloid dendritic cells (mDCs) and monocytes, especially on cytokines/chemok...

Renal abnormalities in rheumatoid arthritis: an insight on IgA nephropathy

Human Bone Marrow Mesenchymal Stromal/Stem Cells Regulate the Proinflammatory R...

Rheumatoid arthritis (RA) is a disabling autoimmune disease whose treatment is ineffective for one-third of patients. Thus, the immunomodulatory potential of mesenchymal stromal/stem cells (MSCs) makes MSC-based therapy a promising approach to RA. This study aimed to explore the immunomodulatory action of human bone marrow (BM)-MSCs on myeloid dendritic cells (mDCs) and monocytes, especially on cytokines/chemok...

Morphea and Hormonal Therapy: A Possible Association

Morphea is a rare inflammatory disorder with an unknown etiology. We report the case of a 35-years-old woman presenting with an 18-month history of skin thickening on the extremities and trunk, and inflammatory arthralgia. Complaints started 2-weeks after a fertility treatment. The physical exam and workup confirmed the diagnosis of morphea, and the patient started treatment with deflazacort and methotrexate, w...

Garra dos líderes e capital psicológico dos liderados: uma exploração concetual...

A garra (termo aqui traduzido de grit) tem sido encarada como crucial para o sucesso dos indivíduos e a eficácia dos líderes, embora alguns autores não sustentem essa tese. A investigação empírica é escassa e pouco conclusiva. Um possível caminho para melhor compreender este construto passa por considerar condições moderadoras. Aqui discutimos três dessas condições: (1) garra veiculada pelo líder versus garra a...

Laypeople's decision-making in reporting child maltreatment: Child and family c...

Objectives: The process of reporting child maltreatment may be vulnerable to judgment bias, which may, in turn, affect the various stages of the child protection system continuum. In this study, we examine the role of child (gender, race/ethnicity, and age) and family characteristics (family structure and socioeconomic status) in laypeople’s severity assessment and probability of referral of child maltreatment ...