4 documents found, page 1 of 1
Advances in nutraceutical delivery systems: From formulation design for bioavai...
Gonçalves, Raquel F. S.; Martins, Joana T.; Duarte, C. M. M.; Vicente, A. A.; Pinheiro, Ana CristinaBackground: Aiming at the enhancement of food products' nutritional and health value, the incorporation of nutraceuticals has attracted increasing interest in the last years. However, they often exhibit low water solubility and stability, limiting their direct incorporation into food products. Also, they show very low bioavailability due to limited bioaccessibility, poor absorption and/or chemical transformatio...
Development of multicore hybrid particles for drug delivery through the precipi...
Gonçalves, V. S. S.; Rodríguez-Rojo, S.; Matias, A. A.; Nunes, A. V. M.; Nogueira, I. D.; Nunes, D.; Fortunato, E.; Alves de Matos, A. P.; Cocero, M. J.Hybrid lipid–polymer particles are gaining increasing interest to be applied as drug delivery systems due to their greater stability in biological fluids and enhanced cellular uptake of drugs. However, a major drawback is the fact that these particles are usually produced through techniques that use organic solvents. This work studies the possibility of producing for the first time hybrid particles composed by ...
Evaluation of cardiovascular protective effect of different apple varieties - C...
Serra, A. T.; Rocha, J.; Sepodes, B.; Matias, A. A.; Feliciano, R. P.; Carvalho, A. d.; Bronze, M. R.; Duarte, C. M. M.; Figueira, M. E."Epidemiological evidence supports the concept that diets rich in fruits and vegetables promote health and attenuate or delay the onset of cardiovascular disease (CVD). In particular, a reduced risk of CVD has been associated with apple consumption, probably due to the cholesterol-lowering effect of the main bioactive compounds, namely fiber and polyphenols. In this work, the effect of diet supplementation with...
Solubility of dense CO2 in two biocompatible acrylate copolymers
Duarte, A. R. C.; Sousa, A. R. Sampaio de; Sousa, H. C. de; Gil, M. H. M.; Jespersen, H. T.; Duarte, C. M. M.Biocompatible polymers and copolymers are frequently being used as part of controlled delivery systems. These systems can be prepared using a “clean and environment friendly” technology like supercritical fluids. One great advantage of this process is that compressed carbon dioxide has excellent plasticizing properties and can swell most biocompatible polymeric matrixes, thus promoting drug impregnation process...