Introduction and objectives: The association of low-density lipoprotein cholesterol (LDL-C) levels and prognosis in patients with heart failure (HF) remains uncertain. This study aimed to evaluate the prognostic significance of LDL-C in patients admitted for acutely decompensated HF and establish a safety cut-off value in this population. Methods: This retrospective, observational study included 167 consecutive...
Obesity is a clinical condition characterized by an abnormal accumulation of adipose tissue with an increased risk of developing illnesses such as type 2 diabetes, cardiovascular disease, and cancer. In obesity, the secretion of proinflammatory adipokines contributes to oxidative stress that can lead to a decline in the length of telomeres. Telomeres are structures of repetitive sequences delimiting the chromos...
Ocean acidification (OA) is expected to decrease the strength of bivalves' shells, especially during the early stages of development, with negative consequences to the resilience of natural populations and the economy. The objectives of the present study were to assess the long-term effect of increasing pCO(2) after 217 days of exposure under controlled conditions of pH of similar to 8.2, 8.0, and 7.7 on the st...
The effect of Perkinsus olseni infection on the reproduction ability of clams has been underestimated so far. Although some studies found evidence of reduction of egg production and delay in gonad maturation after infection, the total effect of the infection is still unclear. In this study, Ruditapes decussatus clams from a naïve population were injected with two different doses of P. olseni parasites, a low do...
Introduction: Identification of well-appearing infants at risk for early-onset sepsis presents an ongoing challenge. Several guidelines advise categorical risk assessment strategies, resulting in excessive laboratory tests, admissions, and antibiotic use. Currently, approaches using multivariate risk assessment or serial clinical observation are gaining ground. The primary objective of this study was to describ...
Objective: To identify risk factors for SARS-CoV-2 infection and for severe/critical COVID-19, and to assess the humoral response after COVID-19 in these patients. Methods: Nationwide study of adult patients with inflammatory RMDs prospectively followed in the Rheumatic Diseases Portuguese Register-Reuma.pt-during the first 6 months of the pandemic. We compared patients with COVID-19 with those who did not deve...
An emergent research area in software engineering and software reliability is the use of wearable biosensors to monitor the cognitive state of software developers during software development tasks. The goal is to gather physiologic manifestations that can be linked to error-prone scenarios related to programmers' cognitive states. In this paper we investigate whether electroencephalography (EEG) can be applied ...
Introduction: AOM is the most common diagnosis for the prescription of antibiotics in children. The Portuguese National Health Autority issued a clinical guideline in 2012, updated in 2014, in which it recommends the use of amoxicillin as first-line antibiotic. The option is based on the fact that amoxicillin is the most effective oral antibiotic against the microorganisms with the greatest risk for acute inva...
O presente documento foi realizado como Relatório de Estágio no âmbito da unidade curricular Estágio Curricular, com vista à obtenção do grau de Licenciatura em Desporto, na Escola Superior de Educação, Comunicação e Desporto, do Instituto Politécnico da Guarda. Com este relatório, ficamos a conhecer a caraterização da entidade acolhedora (Stadius Fitness Club), objetivos e planeamento do estágio, atividades de...
A ressonância magnética functional(RMf) é uma técnica ainda relativamente recente, tendo surgido no início dos anos 90 do século passado, quando Ogawa(Ogawa et al., 1992) e Bandettini (Bandettini et al., 1992) demonstraram que o sinal hemodinâmico BOLD, com origem no contraste de sinal T2*, se alterava de forma correspondente ao padrão de estimulação sensorial. Esta técnica permaneceu controversa desde o início...