11 documents found, page 1 of 2
Urine Metabolomics during a Legume Diet Intervention Suggests Altered Metabolic...
Ferreira, H; Duarte, D; Rodrigues, JA; Vasconcelos, MW; Pinto, E; Gil, AMGiven the general increase in legume consumption worldwide, there is a need to characterize the resulting human metabolic adaptations in order to demonstrate potential legume diet/health relationships. A nuclear magnetic resonance (NMR) metabolomics urine study was carried out on a small cohort (n = 18) to characterize the excretory effects of a pilot longitudinal 8-week legume-based dietary intervention. Despi...
Impact of a legumes diet on the human gut microbiome articulated with fecal and...
Ferreira, H; Duarte, D; Carneiro, TJ; Costa, C; Barbosa, JC; Rodrigues, JE; Alves, P; Vasconcelos, M; Pinto, E; Gomes, A; Gil, AMBackground & aims: Legumes intake is known to be associated with several health benefits the origins of which is still a matter of debate. This paper addresses a pilot small cohort to probe for metabolic aspects of the interplay between legumes intake, human metabolism and gut microbiota. Methods: Untargeted nuclear magnetic resonance (NMR) metabolomics of blood plasma and fecal extracts was carried out, in tan...
Investigation of the Anticancer and Drug Combination Potential of Brominated Co...
Magalhaes, CM; Gonzalez-Berdullas, P; Pereira, M; Duarte, D; Nuno Vale; Joaquim C G E Esteves da Silva; da Silva, LPCancer is a very challenging disease to treat, both in terms of therapeutic efficiency and harmful side effects, which continues to motivate the pursuit for novel molecules with potential anticancer activity. Herein, we have designed, synthesized, and evaluated the cytotoxicity of different brominated coelenteramines, which are metabolic products and synthesis precursors of the chemi-/bioluminescent system of m...
Model amphipathic peptide coupled with tacrine to improve its antiproliferative...
Silva, S; Alves, C; Duarte, D; Costa, A; Sarmento, B; Almeida, AJ; Gomes, P; Vale, NDrug repurposing and drug combination are two strategies that have been widely used to overcome the traditional development of new anticancer drugs. Several FDA-approved drugs for other indications have been tested and have demonstrated beneficial anticancer effects. In this connection, our research group recently reported that Tacrine, used to treat Alzheimer’s Disease, inhibits the growth of breast cancer MCF...
Target-Oriented Synthesis of Marine Coelenterazine Derivatives with Anticancer ...
Magalhaes, CM; Gonzalez Berdullas, P; Duarte, D; Correia, AS; Rodriguez Borges, JE; Nuno Vale; Joaquim C G E Esteves da Silva; da Silva, LPPhotodynamic therapy (PDT) is an anticancer therapeutic modality with remarkable advantages over more conventional approaches. However, PDT is greatly limited by its dependence on external light sources. Given this, PDT would benefit from new systems capable of a light-free and intracellular photodynamic effect. Herein, we evaluated the heavy-atom effect as a strategy to provide anticancer activity to derivativ...
The Dynamic Interface Between the Bone Marrow Vascular Niche and Hematopoietic ...
Mosteo, L; Storer, J; Batta, K; Searle, EJ; Duarte, D; Wiseman, DHHematopoietic stem cells interact with bone marrow niches, including highly specialized blood vessels. Recent studies have revealed the phenotypic and functional heterogeneity of bone marrow endothelial cells. This has facilitated the analysis of the vascular microenvironment in steady state and malignant hematopoiesis. In this review, we provide an overview of the bone marrow microenvironment, focusing on refi...
Anti-remodeling effects of xanthohumol-fortified beer in pulmonary arterial hyp...
Silva, AF; Faria-Costa, G; Sousa-Nunes, F; Santos, MF; Ferreira-Pinto, MJ; Duarte, D; Rodrigues, I; Guimarães, JT; Leite-Moreira, APolyphenols present in some alcoholic beverages have been linked to beneficial effects in preventing cardiovascular diseases. Polyphenols found in beer with anti-proliferative and anti-cancer properties are appealing in the context of the quasi-malignant phenotype of pulmonary arterial hypertension (PAH). Our purpose was to evaluate if the chronic ingestion of a xanthohumol-fortified beer (FB) would be able to ...
Study of the combination of self-activating photodynamic therapy and chemothera...
Silva, LP; Magalhães, CM; Núñez-Montenegro, A; Ferreira, PJO; Duarte, D; Rodríguez-Borges, JE; Vale, N; Silva, JCGECancer is a very challenging disease to treat, both in terms of treatment eficiency and side-effects. To overcome these problems, there have been extensive studies regarding the possibility of improving treatment by employing combination therapy, and by exploring therapeutic modalities with reduced side-effects (such as photodynamic therapy (PDT)). Herein, this work has two aims: (i) to develop self-activating ...
Carbidopa alters tryptophan metabolism in breast cancer and melanoma cells lead...
Duarte, D; Amaro, F; Silva, I; Silva, D; Fresco, P; Oliveira, JC; Reguengo, H; Gonçalves, J; Vale, NCarbidopa is used for the treatment of Parkinson’s disease (PD) as an inhibitor of DOPA decarboxylase, and PD patients taking carbidopa have a lower incidence of various tumors, except for breast cancer andmelanoma. Recently, itwas shown that carbidopa inhibits tryptophan-2,3-dioxygenase (TDO) and kynureninase enzymes. In the present study, the effect of carbidopa on the viability and metabolic profile of breas...
Newborn Urinary Metabolic Signatures of Prematurity and Other Disorders: A Case...
Diaz, SO; Pinto, JJ; Barros, AS; Morais, E; Duarte, D; Negrão, F; Pita, C; Almeida, MC; Carreira, IM; Spraul, M; Gil, AMThis work assesses the urinary metabolite signature of prematurity in newborns by nuclear magnetic resonance (NMR) spectroscopy, while establishing the role of possible confounders and signature specificity, through comparison to other disorders. Gender and delivery mode are shown to impact importantly on newborn urine composition, their analysis pointing out at specific metabolite variations requiring consider...