19 documents found, page 1 of 2

Facile access to structurally diverse antimalarial indoles using a one‐pot A3 c...

© 2023 Wiley-VCH GmbH; A multistep and diversity-oriented synthetic route aiming at the A3 coupling/domino cyclization of o-ethynyl anilines, aldehydes and s-amines is described. The preparation of the corresponding precursors included a series of transformations, such as haloperoxidation and Sonogashira cross-coupling reactions, amine protection, desilylation and amine reduction. Some products of the multicomp...

Facile Access to Structurally Diverse Antimalarial Indoles Using a One-Pot A3 C...

A multistep and diversity-oriented synthetic route aiming at the A3 coupling/domino cyclization of o-ethynyl anilines, aldehydes and s-amines is described. The preparation of the corresponding precursors included a series of transformations, such as haloperoxidation and Sonogashira cross-coupling reactions, amine protection, desilylation and amine reduction. Some products of the multicomponent reaction underwen...

Drug‐derived surface‐active ionic liquids: a cost‐effective way to expressively...

© 2021 Wiley-VCH GmbH; Inspired by previous disclosure of room-temperature ionic liquids derived from primaquine and cinnamic acids, which displayed slightly enhanced blood-stage activity compared to the parent drug, we have now combined this emblematic antimalarial with natural fatty acids. This affords surface-active ionic liquids whose liver-stage antiplasmodial activity is either retained or slightly enhanc...

Drug-derived surface-active ionic liquids: a cost-effective way to expressively...

Inspired by previous disclosure of room-temperature ionic liquids derived from primaquine and cinnamic acids, which displayed slightly enhanced blood-stage activity compared to the parent drug, we have now combined this emblematic antimalarial with natural fatty acids. This affords surface-active ionic liquids whose liver-stage antiplasmodial activity is either retained or slightly enhanced, while revealing blo...

Adequação terapêutica da utilização de inibidores da bomba de protões: estudo e...

O aumento acentuado do consumo de fármacos inibidores da bomba de protões (IBPs) que se tem verificado nos últimos cinco anos fez surgir a necessidade de analisar a sua utilização na prática clínica atual e avaliar as possíveis consequências associadas ao seu consumo. Pretendeu-se com este estudo analisar a adequação terapêutica da utilização de IBPs na prática clínica de uma farmácia comunitária.

Surgical site infection in patients submitted to orthopedic surgery: the NNIS r...

La aplicabilidad del Índice de Riesgo de Infección Quirúrgica del National Nosocomial Infection Surveillance-NNIS ha sido evaluada en cuanto a su desempeño en diferentes cirugías. En algunos procedimientos es necesaria la inclusión de otras variables de predicción. El objetivo de este estudio fue evaluar la aplicabilidad del Índice NNIS para la predicción de la Infección de Sitio Quirúrgico en cirugías ortopédi...

Apresentação

Apresentação

João Filgueiras Lima (Lelé)

Pesquisa em arquitetura e urbanismo: Guia prático para o trabalho de pesquisado...