5 documents found, page 1 of 1
Toxicological Profile of Umbilical Cord Blood-Derived Small Extracellular Vesicles
Rodrigues, Sílvia C.; Cardoso, Renato M. S.; Gomes, Claudia F.; Duarte, Filipe Valente; Freire, Patricia C.; Neves, Ricardo; Correia, Joana SimõesThe development and adoption of cell therapies has been largely limited by difficulties associated with their safety, handling, and storage. Extracellular vesicles (EV) have recently emerged as a likely mediator for the therapeutic effect of cells, offering several advantages over cell therapies. Due to their small size and inability to expand and metastasize, EV are generally considered safer than cell transpl...
Mitochondrial damage and apoptosis: Key features in BDE-153-induced hepatotoxicity
Pereira, Lilian Cristina [UNESP]; Cabral Miranda, Luiz Felipe; Franco-Bernardes, Mariana Furio; Tasso, Maria Julia; Duarte, Filipe ValenteMade available in DSpace on 2018-12-11T17:21:03Z (GMT). No. of bitstreams: 0 Previous issue date: 2018-08-01; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Universidade de São Paulo; Brominated flame retardants are used in consumer goods to increase product resistance to fire and/or high temperatures. Polybrominated dip...
Exposure to BDE-153 induces autophagy in HepG2 cells
Pereira, Lilian Cristina [UNESP]; Duarte, Filipe Valente; Varela, Ana Teresa Inácio Ferreira; Rolo, Anabela Pinto; Palmeira, Carlos Manuel MarquesMade available in DSpace on 2018-12-11T17:23:27Z (GMT). No. of bitstreams: 0 Previous issue date: 2017-08-01; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES); Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Autophagy is a pro-survival process that occurs under stressful “life-threatening” conditions. This pr...
Berberine reverts hepatic mitochondrial dysfunction in high-fat fed rats: A pos...
Teodoro, João Soeiro; Duarte, Filipe Valente; Gomes, Ana Patrícia; Varela, Ana Teresa; Peixoto, Francisco Manuel; Rolo, Anabela Pinto; Palmeira, C. M.Berberine is an isoquinoline alkaloid with anti-diabetic properties. Despite the central role of liver and thus hepaticmitochondria inwhole-bodymetabolism, berberine effects on hepaticmitochondrial function in an obesity model are still unknown. Here, we demonstrate that berberine treatment recovers mitochondrial efficiency when altered by a high-fat feeding.Mitochondria isolated from the liver of high-fat fed ...
Dibenzofuran exposure: cellular and mitochondrial damage
Duarte, Filipe ValenteTese de doutoramento em Biociências, no ramo de especialização em Biologia Celular e Molecular, apresentada à Faculdade de Ciências e Tecnologia da Universidade de Coimbra; In the modern world, one of the main issues that mankind tries to control and improve, concerning its well-being, is health. In the last decades, several progresses have been achieved in order to improve health and also to increase overall l...