30 documents found, page 1 of 3
Catatonia in dementia: a systematic review of case reports and case series
Câmara Pestana, Pedro; Estibeiro, Maria João; Côrte-Real, Beatriz; Cordeiro, Catarina; Simões, Inês; Duarte, Gonçalo Silva; Simões Do Couto, FredericoBackground: Catatonia is a neuropsychiatric syndrome characterized by motor, behavioral, and autonomic abnormalities. It is often underdiagnosed in geriatric patients with dementia despite established diagnostic criteria and treatment options. Objective: This systematic review investigates catatonia in the elderly, particularly those with dementia, to examine their clinical presentation, treatment response, and...
Prognosis of polymerase epsilon (POLE) mutation in high-grade endometrioid endo...
Casanova, Joao; Duarte, Gonçalo Silva; da Costa, Ana Gomes; Catarino, Ana; Nave, Mónica; Antunes, Telma; Serra, Sofia Silvério; Dias, Sara SimõesBackground. POLE mutated endometrial carcinomas may represent a subspecific type of tumors harboring a more favorable prognosis. Grade 3 (G3 or high-grade) endometrioid endometrial carcinomas remain a clinical dilemma, with some tumors behaving as the low-grade counterparts and others presenting a more aggressive behavior. Objectives. To determine the association between POLE mutational status and the overall-s...
Immune-related serious adverse events with immune checkpoint inhibitors: system...
Oliveira, Clara; Mainoli, Beatrice; Duarte, Gonçalo Silva; Machado, Tiago; Tinoco, Rita G.; Esperança Martins, Miguel; Ferreira, Joaquim J; Costa, JoãoPurpose: Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment, though uncertainty exists regarding their immune-related safety. The objective of this study was to assess the comparative safety profile (odds ratio) of ICIs and estimate the absolute rate of immune-related serious adverse events (irSAEs) in cancer patients undergoing treatment with ICIs. Methods: We searched for randomized tria...
Incidence and prevalence of thoracic aortic aneurysms: a systematic review and ...
Melo, Ryan; Duarte, Gonçalo Silva; Lopes, Alice; Alves, Mariana; Caldeira, Daniel; Fernandes E Fernandes, Ruy; Pedro, Luís MThoracic aortic aneurysms (TAA) may grow asymptomatically until they rupture, with a mortality over 90%. The true incidence and prevalence of this condition is uncertain and epidemiologic data is scarce, understudied and dispersed. Therefore, we aimed to conduct a systematic review and meta-analysis of the incidence and prevalence of TAAs in population-based studies. We searched MEDLINE, EMBASE and CENTRAL from...
A MDS evidence‐based review on treatments for Huntington's Disease
Ferreira, Joaquim J; Rodrigues, Filipe Brogueira; Duarte, Gonçalo Silva; Mestre, Tiago; Bachoud‐Levi, Anne‐Catherine; Bentivoglio, Anna RitaBackground: Huntington's disease (HD) is a rare neurodegenerative disorder with protean clinical manifestations. Its management is challenging, consisting mainly of off-label treatments. Objectives: The International Parkinson and Movement Disorder Society commissioned a task force to review and evaluate the evidence of available therapies for HD gene expansion carriers. Methods: We followed the Grading of Reco...
Analysis of clinical and methodological characteristics of early COVID-19 treat...
Mainoli, Beatrice; Machado, Tiago; Duarte, Gonçalo Silva; Prada, Luísa; Gonçalves, Nilza; Ferreira, Joaquim J; Costa, JoãoBackground: The COVID-19 pandemic continues to rage on, and clinical research has been promoted worldwide. We aimed to assess the clinical and methodological characteristics of treatment clinical trials that have been set forth as an early response to the COVID-19 pandemic. Methods: First, we reviewed all registered clinical trials on COVID-19. The World Health Organization International Trials Registry Platfor...
Satisfaction of patients with nonvitamin K anticoagulants compared to vitamin K...
Katerenchuk, Vasyl; Duarte, Gonçalo Silva; Martins E Pereira, Gonçalo; Fernandes, Ricardo M.; Ferreira, Joaquim J; Pinto, Fausto J.; Costa, JoãoOBJECTIVE: To undertake a systematic review and meta-analysis to assess the satisfaction of patients receiving nonvitamin K anticoagulants (NOACs), compared with vitamin K antagonists (VKAs). METHODS: We searched CENTRAL, MEDLINE, Embase, and Clinicaltrials.gov for randomized controlled trials (RCTs) and observational studies. Two reviewers screened, extracted, and appraised data independently. We pooled data u...
Synchronous and metachronous thoracic aortic aneurysms in patients with abdomin...
Melo, Ryan; Duarte, Gonçalo Silva; Lopes, Alice; Alves, Mariana; Caldeira, Daniel; Fernandes, Ruy Fernandes e; Pedro, Luís MBackground: The prevalence of thoracic aortic aneurysms (TAA) in patients with known abdominal aortic aneurysms (AAA) is not well known and understudied. Our aim was to conduct a systematic review and meta‐analysis of the overall prevalence of synchronous and metachronous TAA (SM‐TAA) in patients with a known AAA and to understand the characteristics of this sub‐population. Methods and Results: We searched MEDL...
Quality and risk of bias appraisals of systematic reviews are inconsistent acro...
Gates, Michelle; Gates, Allison; Duarte, Gonçalo Silva; Cary, Maria; Becker, Monika; Prediger, Barbara; Vandermeer, Ben; Fernandes, Ricardo M.Objective: The objective of the study was to evaluate the inter-rater and intercenter reliability, usability, and utility of A MeaSurement Tool to Assess systematic Reviews (AMSTAR), AMSTAR 2, and Risk Of Bias In Systematic reviews (ROBIS). Study design and setting: This is a prospective evaluation using 30 systematic reviews of randomized trials, undertaken at three international centers. Results: Reviewers co...
Cardiovascular events reported in randomized controlled trials in restless legs...
Duarte, Gonçalo Silva; Alves, Mariana; Silva, Maria A.; Câmara, Raquel; Caldeira, Daniel; Ferreira, Joaquim J.Objective: Evaluate the frequency of cardiovascular adverse events reported in randomized controlled trials (RCT) in Restless Leg Syndrome (RLS). Methods: Databases were searched up to October 2015. Randomized, double-blind, placebo-controlled trials of patients with RLS were included if quantitative data were extractable. The primary outcome was cardiovascular adverse events defined as cardiac diseases, blood ...